Cabal L A, Larrazabal C, Ramanathan R, Durand M, Lewis D, Siassi B, Hodgman J
J Pediatr. 1987 Jan;110(1):116-9. doi: 10.1016/s0022-3476(87)80302-5.
Changes in pulmonary resistance, dynamic compliance, tidal volume, and transcutaneous PO2 and PCO2 after nebulized administration of metaproterenol were evaluated in eight newborn infants (birth weight 650 to 1060 g, gestational age 25 to 28 weeks) with chronic lung disease receiving mechanical ventilation. The infants were monitored continuously before and for 15 minutes after nebulization of metaproterenol during 3 consecutive days at mean age 34 days. There were significant increases in compliance, tidal volume, and tcPO2, and significant decreases in pulmonary resistance and tcPCO2. These data show that bronchospasm contributes significantly to the high pulmonary resistance in preterm infants with chronic lung disease and that metaproterenol is beneficial in the therapy of infants with chronic lung disease requiring mechanical ventilation.
对八名患有慢性肺病且正在接受机械通气的新生儿（出生体重650至1060克，胎龄25至28周）雾化吸入间羟异丙肾上腺素后肺阻力、动态顺应性、潮气量以及经皮氧分压和二氧化碳分压的变化进行了评估。在平均年龄34天时，连续三天在雾化吸入间羟异丙肾上腺素之前及之后15分钟对婴儿进行持续监测。顺应性、潮气量和经皮氧分压显著增加，肺阻力和经皮二氧化碳分压显著降低。这些数据表明，支气管痉挛在患有慢性肺病的早产儿的高肺阻力中起重要作用，且间羟异丙肾上腺素对需要机械通气的慢性肺病婴儿的治疗有益。
