Zempo-Miyaki Asako, Kumagai Hiroshi, Tanahashi Koichiro, Zempo Hirofumi, Otsuki Takeshi, Maeda Seiji
Faculty of Sport & Health Sciences, Ryutsu Keizai University, Ibaraki, Japan.
Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.
J Obes Metab Syndr. 2023 Dec 30;32(4):330-337. doi: 10.7570/jomes23027. Epub 2023 Nov 13.
Levels of pentraxin 3 (PTX3), an anti-inflammatory cardioprotective protein, increase after weight loss in obese men and aerobic exercise in non-obese adults. However, the effect of nutritional characteristics on PTX3 levels remains unclear. This population-based, cross-sectional study investigated the association between circulating PTX3 levels and food intake in Japanese adults.
We hypothesized that the consumption of high amounts of high-sugar foods would lead to low plasma PTX3 levels, resulting in obesity. This study included 327 participants categorized depending on the consumption of the recommended amount of confectionary and sugar-sweetened beverages (CSSB) into high and low groups.
PTX3 levels were significantly lower in the high CSSB group than in the low CSSB group. Biological sex was the strongest effector of PTX3 levels. Moreover, the intake of Tsukudani and CSSB, as well as some metabolic syndrome factors, also affect PTX3 levels. In the groups categorized by sex and age, the determinants of PTX3 levels differed. Body mass index, waist circumference (WC), and high-density lipoprotein cholesterol (HDL-C) were significantly associated with PTX3 levels in women. Tsukudani, HDL-C, heart rate, saturated fatty acids, systolic blood pressure, and CSSB were associated with PTX3 levels in individuals aged >65 years.
Our results show that circulating PTX3 levels are affected by sex, sugar-rich foods, and metabolic syndrome characteristics (WC, HDL-C).
五聚体3（PTX3）是一种具有抗炎心脏保护作用的蛋白质，在肥胖男性体重减轻后以及非肥胖成年人进行有氧运动后其水平会升高。然而，营养特征对PTX3水平的影响仍不清楚。这项基于人群的横断面研究调查了日本成年人循环PTX3水平与食物摄入量之间的关联。
我们假设大量食用高糖食物会导致血浆PTX3水平降低，进而导致肥胖。本研究纳入了327名参与者，根据糖果和含糖饮料（CSSB）的推荐摄入量分为高摄入组和低摄入组。
高CSSB组的PTX3水平显著低于低CSSB组。生物性别是PTX3水平的最强影响因素。此外，佃煮和CSSB的摄入量以及一些代谢综合征因素也会影响PTX3水平。在按性别和年龄分类的组中，PTX3水平的决定因素有所不同。体重指数、腰围（WC）和高密度脂蛋白胆固醇（HDL-C）与女性的PTX3水平显著相关。佃煮、HDL-C、心率、饱和脂肪酸、收缩压和CSSB与65岁以上个体的PTX3水平相关。
我们的结果表明，循环PTX3水平受性别、富含糖的食物和代谢综合征特征（WC、HDL-C）的影响。
