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冷凝集素病合并肺血栓形成致机化性肺炎 1 例

Organizing Pneumonia in a Case of Cold Agglutinin Disease with Pulmonary Thrombosis.

机构信息

Department of Pulmonary Medicine, Graduate School of Comprehensive Human Science, University of Tsukuba, Japan.

Department of Respiratory Medicine, National Hospital Organization, Ibaraki Higashi National Hospital, Japan.

出版信息

Intern Med. 2024 Jun 15;63(12):1801-1806. doi: 10.2169/internalmedicine.2368-23. Epub 2023 Nov 13.

DOI:10.2169/internalmedicine.2368-23
PMID:37952958
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11239267/
Abstract

Cold agglutinin disease is a subtype of autoimmune hemolytic anemia that occurs via the activation of specific anti-red blood cell antibodies (agglutinins) at low temperatures. Autoimmune hemolytic anemia has been reported to cause interstitial pneumonia; however, the underlying mechanism remains unclear. We herein report a 46-year-old man diagnosed with cold agglutinin disease complicated by pulmonary thrombosis and organizing pneumonia. Treatment with prednisolone improved the course of cold agglutinin disease and organizing pneumonia in a similar manner. To our knowledge, this is the first report of cold agglutinin associated with organizing pneumonia, suggesting a potential link between the two.

摘要

冷凝集素病是一种自身免疫性溶血性贫血的亚型，发生于低温下特异性抗红细胞抗体（凝集素）的激活。自身免疫性溶血性贫血已被报道可导致间质性肺炎；然而，其潜在机制尚不清楚。本文报告了一例 46 岁男性冷凝集素病合并肺血栓栓塞症和机化性肺炎。泼尼松龙治疗以相似的方式改善了冷凝集素病和机化性肺炎的病程。据我们所知，这是首例冷凝集素相关机化性肺炎的报告，提示两者之间可能存在关联。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a100/11239267/7e7cca95a83b/1349-7235-63-1801-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a100/11239267/fec59a9b506c/1349-7235-63-1801-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a100/11239267/76ce0ff8635b/1349-7235-63-1801-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a100/11239267/dbf44e40d74f/1349-7235-63-1801-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a100/11239267/5e53706c1a58/1349-7235-63-1801-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a100/11239267/7e7cca95a83b/1349-7235-63-1801-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a100/11239267/fec59a9b506c/1349-7235-63-1801-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a100/11239267/76ce0ff8635b/1349-7235-63-1801-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a100/11239267/dbf44e40d74f/1349-7235-63-1801-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a100/11239267/5e53706c1a58/1349-7235-63-1801-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a100/11239267/7e7cca95a83b/1349-7235-63-1801-g005.jpg

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1
Organizing Pneumonia in a Case of Cold Agglutinin Disease with Pulmonary Thrombosis.冷凝集素病合并肺血栓形成致机化性肺炎 1 例
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本文引用的文献

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Cold Agglutinin Disease.冷凝集素病
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Autoimmune hemolytic anemia.自身免疫性溶血性贫血。
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Cold agglutinin disease.冷凝集素病
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New Insights in the Pathogenesis of Autoimmune Hemolytic Anemia.自身免疫性溶血性贫血发病机制的新见解
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