European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, Cambridgeshire CB10 1SD, UK.
Cold Spring Harbor Laboratory, 1 Bungtown Rd, Cold Spring Harbor, NY 11724, USA.
Nucleic Acids Res. 2024 Jan 5;52(D1):D891-D899. doi: 10.1093/nar/gkad1049.
Ensembl (https://www.ensembl.org) is a freely available genomic resource that has produced high-quality annotations, tools, and services for vertebrates and model organisms for more than two decades. In recent years, there has been a dramatic shift in the genomic landscape, with a large increase in the number and phylogenetic breadth of high-quality reference genomes, alongside major advances in the pan-genome representations of higher species. In order to support these efforts and accelerate downstream research, Ensembl continues to focus on scaling for the rapid annotation of new genome assemblies, developing new methods for comparative analysis, and expanding the depth and quality of our genome annotations. This year we have continued our expansion to support global biodiversity research, doubling the number of annotated genomes we support on our Rapid Release site to over 1700, driven by our close collaboration with biodiversity projects such as Darwin Tree of Life. We have also strengthened support for key agricultural species, including the first regulatory builds for farmed animals, and have updated key tools and resources that support the global scientific community, notably the Ensembl Variant Effect Predictor. Ensembl data, software, and tools are freely available.
Ensembl（https://www.ensembl.org）是一个免费的基因组资源，二十多年来，它为脊椎动物和模式生物生成了高质量的注释、工具和服务。近年来，基因组图谱发生了巨大变化，高质量参考基因组的数量和系统发育范围大幅增加，同时高等物种的泛基因组表示也取得了重大进展。为了支持这些努力并加速下游研究，Ensembl 继续专注于快速注释新基因组组装的扩展，开发用于比较分析的新方法，并扩展我们基因组注释的深度和质量。今年，我们继续扩大规模以支持全球生物多样性研究，通过与达尔文生命之树等生物多样性项目的密切合作，我们在快速发布网站上支持的注释基因组数量增加了一倍，超过 1700 个。我们还加强了对关键农业物种的支持，包括首次为养殖动物构建调控构建，并且更新了支持全球科学界的关键工具和资源，特别是 Ensembl Variant Effect Predictor。Ensembl 数据、软件和工具都是免费提供的。
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