Pang Nicole Girlyn T, Batara Julette Marie F, Luistro Lara Triccia C, Mojica Christianne V, Domingo Allan Jay C
Institute for Neurosciences, St. Luke's Medical Center-Quezon City and Global City, Philippines.
Department of Neurosciences, College of Medicine and Philippine General Hospital, University of the Philippines Manila, Manila, Philippines.
Brain Tumor Res Treat. 2023 Oct;11(4):239-245. doi: 10.14791/btrt.2023.0022.
Thallium-201 single-photon emission computed tomography/computed tomography (SPECT/CT) brain scan is an imaging modality which can be done to differentiate between malignant and nonmalignant lesions among patients with nonconclusive findings on conventional neuroimaging. This study describes the results of thallium-201 SPECT/CT brain imaging and relate it to histopathologic and/or clinical findings and evaluate the value of thallium-201 SPECT/CT brain imaging in differentiating malignant from nonmalignant lesions.
This is a retrospective case series study of 10 patients with cerebral lesions who underwent thallium-201 SPECT/CT brain imaging in a hospital in the Philippines from 2010 to 2021.
A total of 10 patients underwent thallium-201 SPECT/CT brain scan. Six had negative results while 4 had positive results. All of the patients who had positive results were found to have malignancy, whether recurrent or newly diagnosed. All of the patients with negative scan were found to have either an infectious and inflammatory disease and responded to treatment albeit in different degrees. Two of the 10 patients underwent biopsy whose results were consistent with the thallium-201 SPECT/CT brain scan results.
Thallium-201 brain scan combined with SPECT and SPECT/CT has been demonstrated to be useful in distinguishing malignant from nonmalignant lesions and is more cost-effective versus other imaging techniques. The findings in this study support the role of thallium scintigraphy in the diagnosis of patients with brain lesions most significantly when there is a need to differentiate between a malignant and benign condition.
铊-201单光子发射计算机断层扫描/计算机断层扫描（SPECT/CT）脑部扫描是一种成像方式，可用于在传统神经影像学检查结果不明确的患者中区分恶性和非恶性病变。本研究描述了铊-201 SPECT/CT脑部成像的结果，并将其与组织病理学和/或临床结果相关联，评估铊-201 SPECT/CT脑部成像在区分恶性和非恶性病变方面的价值。
这是一项回顾性病例系列研究，对2010年至2021年在菲律宾一家医院接受铊-201 SPECT/CT脑部成像的10例脑部病变患者进行了研究。
共有10例患者接受了铊-201 SPECT/CT脑部扫描。6例结果为阴性，4例结果为阳性。所有结果为阳性的患者均被发现患有恶性肿瘤，无论是复发还是新诊断的。所有扫描结果为阴性的患者均被发现患有感染性和炎症性疾病，尽管治疗反应程度不同。10例患者中有2例接受了活检，其结果与铊-201 SPECT/CT脑部扫描结果一致。
铊-201脑部扫描结合SPECT和SPECT/CT已被证明有助于区分恶性和非恶性病变，并且与其他成像技术相比更具成本效益。本研究结果支持铊闪烁显像在诊断脑部病变患者中的作用，尤其是在需要区分恶性和良性情况时。
