运动训练可上调人体内烟酰胺磷酸核糖基转移酶的表达：系统评价与荟萃分析。
Exercise training upregulates intracellular nicotinamide phosphoribosyltransferase expression in humans: a systematic review with meta-analysis.
机构信息
College of Physical Education, Hunan Normal University, Changsha, China.
School of Humanities, Inner Mongolia University of Technology, Hohhot, China.
出版信息
Front Public Health. 2023 Oct 26;11:1287421. doi: 10.3389/fpubh.2023.1287421. eCollection 2023.
OBJECTIVE
Aging is associated with decreased nicotinamide adenine dinucleotide (NAD) levels, which in turn cause dysfunctional mitochondria and indirectly affect a myriad of diseases. Intracellular nicotinamide phosphoribosyltransferase (iNAMPT) serves as a central rate-limiting enzyme in NAD synthesis, making it an indispensable health mediator. This meta-analysis examined the effect of exercise training on the expression of iNAMPT in humans.
METHODS
We searched PubMed, Scopus, ClinicalTrials.gov, and the International Clinical Trials Registry Platform for studies published between the inception of the database and July 5, 2023. Using the common-effect model, evidence for the change in iNAMPT following exercise training was synthesized as Cohen's .
RESULTS
The search yielded five eligible studies. The overall effect size is 0.81, with a 95% confidence interval of 0.55 to 1.07. Therefore, a random adult will have a 71.7% probability that iNAMPT will be up-regulated following exercise training. In general, exercise training resulted in a 1.46-fold increase in iNAMPT. Our probability statistics indicate that subgroups of interest may differ practically. Specifically, there is a 79.3% probability of increased iNAMPT in men, compared to a 69.0% probability in the overall population; young adults have a 75.6% probability of having an increased iNAMPT, whereas aged adults have a 68.7% probability; and, iNAMPT has a 75.1% probability increase after aerobic exercise and a 66.4% probability increase after resistance exercise.
CONCLUSION
Exercise training is effective for increasing iNAMPT levels in skeletal muscles. This essential enzyme regulates not only cellular energetics but also healthspan. Therefore, exercise should be promoted as a natural slow-aging lifestyle.
目的
衰老与烟酰胺腺嘌呤二核苷酸 (NAD) 水平降低有关，而 NAD 水平降低又会导致线粒体功能障碍，并间接影响众多疾病。细胞内烟酰胺磷酸核糖转移酶 (iNAMPT) 作为 NAD 合成的核心限速酶，是不可或缺的健康调节剂。本荟萃分析研究了运动训练对人类 iNAMPT 表达的影响。
方法
我们检索了 PubMed、Scopus、ClinicalTrials.gov 和国际临床试验注册平台，检索时间为数据库建立至 2023 年 7 月 5 日期间发表的研究。采用共同效应模型，综合运动训练后 iNAMPT 变化的证据，以 Cohen's 表示。
结果
搜索结果得到五项符合条件的研究。总体效应量为 0.81，95%置信区间为 0.55 至 1.07。因此，随机成年人在运动训练后 iNAMPT 上调的概率为 71.7%。一般来说，运动训练使 iNAMPT 增加了 1.46 倍。我们的概率统计表明，感兴趣的亚组可能在实践中存在差异。具体来说，男性 iNAMPT 增加的概率为 79.3%，而总体人群为 69.0%；年轻人 iNAMPT 增加的概率为 75.6%，而老年人为 68.7%；有氧运动后 iNAMPT 增加的概率为 75.1%，抗阻运动后增加的概率为 66.4%。
结论
运动训练可有效增加骨骼肌 iNAMPT 水平。这种必需酶不仅调节细胞能量代谢，还调节健康寿命。因此，应提倡运动作为一种自然的延缓衰老的生活方式。
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