Nagaria Tapesh D, Shinde Raju K, Shukla Samarth, Acharya Sourya, Acharya Neema, Jogdand Sangita D
General Surgery, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education and Research, Wardha, IND.
Pathology, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education and Research, Wardha, IND.
Cureus. 2023 Oct 10;15(10):e46819. doi: 10.7759/cureus.46819. eCollection 2023 Oct.
This review delves into the intricate relationship between Vitamin D and patient outcomes in the Surgical Intensive Care Unit (SICU). Vitamin D, known for its multifaceted roles in immune modulation, inflammation regulation, and maintenance of calcium homeostasis, emerges as a pivotal factor in the care of critically ill patients. Our exploration reveals a high prevalence of Vitamin D deficiency in the SICU, primarily attributable to limited sunlight exposure, comorbidities, and medication use. Importantly, Vitamin D status impacts infection rates, mortality, and length of stay in the SICU, making it a clinically relevant consideration. Mechanistic insights into the immunomodulatory and anti-inflammatory effects of Vitamin D shed light on its potential benefits in critical care. However, challenges, including accurate assessment, individualised supplementation, and ethical considerations regarding sunlight exposure, are evident. The prospect of personalised Vitamin D supplementation strategies offers promise for optimising patient care. In conclusion, the Sunlight-Vitamin D Connection holds significant potential to improve outcomes in the SICU, emphasising the importance of further research and tailored approaches for the well-being of critically ill individuals.
本综述深入探讨了维生素D与外科重症监护病房（SICU）患者预后之间的复杂关系。维生素D以其在免疫调节、炎症调控和维持钙稳态方面的多方面作用而闻名，已成为重症患者护理中的关键因素。我们的研究发现，SICU中维生素D缺乏的发生率很高，这主要归因于阳光照射有限、合并症和药物使用。重要的是，维生素D状态会影响SICU中的感染率、死亡率和住院时间，使其成为一个具有临床相关性的考虑因素。对维生素D免疫调节和抗炎作用的机制性见解揭示了其在重症监护中的潜在益处。然而，挑战也很明显，包括准确评估、个性化补充以及与阳光照射相关的伦理考量。个性化维生素D补充策略的前景为优化患者护理带来了希望。总之，阳光 - 维生素D关联对于改善SICU患者的预后具有巨大潜力，强调了进一步研究和为重症患者的健康制定针对性方法的重要性。
