糖尿病视网膜病变:药理学考量
Diabetic Retinopathy: A Pharmacological Consideration.
作者信息
Maheshwari Saket Y, Kumar Sunil, Sinha Arya Harshyt, Kumar Mayank
机构信息
Medicine, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education and Research, Wardha, IND.
Anatomy, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education and Research, Wardha, IND.
出版信息
Cureus. 2023 Oct 11;15(10):e46842. doi: 10.7759/cureus.46842. eCollection 2023 Oct.
Diabetes mellitus (DM) has become a worldwide problem, endangering the well-being of people. This issue is further aggravated by the increased fatty content in the diet of most of the Indian population. It is a preeminent source of the genesis of morbidity in the citizens of any given continent, including both new-world countries and old ones too. A major stumbling block that diabetes creates in the healthy living of any of its sufferers is a complication called diabetic retinopathy (DR), which, in its most elementary and perspicuous form, refers to damage to the blood vessels in the retina of the human eye that occurs as a result of high serum glucose levels. DR can have many symptoms, including obscure and blurred vision, trouble observing and distinguishing various colors, and eye floaters. One of the most significant reasons for the manifestation of new cases of complete blindness may be attributed to DR. The appearance of lesions in the body's small blood vessels forms the basis of retinopathic detection. The currently accepted approach for the prevention and cure of this ailment targets deterring the microvascular complexities through medicinal agents that are placed directly into the vitreous space, photocoagulation through laser medium (visual perceptivity is balanced), and some other surgeries related to the vitreous chamber. Anti-vascular endothelial growth factor (anti-VEGF) therapy provided to the patient by intravitreal route is, at present, the most crucial process for curing the sufferer of the given illness, as it can result in optical advancement with decreased unfavorable effects.
糖尿病(DM)已成为一个全球性问题,危及人们的健康。印度大多数人口饮食中脂肪含量的增加使这个问题进一步恶化。在任何一个大陆的居民中,包括新大陆国家和旧大陆国家,糖尿病都是发病的主要根源。糖尿病给患者健康生活带来的一个主要障碍是一种叫做糖尿病性视网膜病变(DR)的并发症,其最基本、最明显的形式是由于高血糖水平导致人眼视网膜血管受损。糖尿病性视网膜病变可能有许多症状,包括视力模糊、辨别各种颜色困难以及眼前有漂浮物。完全失明新病例出现的最重要原因之一可能归因于糖尿病性视网膜病变。身体小血管中病变的出现是视网膜病变检测的基础。目前公认的预防和治疗这种疾病的方法旨在通过直接注入玻璃体腔的药物来阻止微血管并发症、通过激光介质进行光凝(平衡视觉感知)以及一些与玻璃体腔相关的其他手术。目前,通过玻璃体腔内途径为患者提供抗血管内皮生长因子(anti-VEGF)治疗是治愈该病患者的最关键过程,因为它可以在减少不良反应的情况下带来视力改善。