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一位58岁患者色素性角膜溃疡的处理

Managing a Pigmented Corneal Ulcer in a 58-Year-Old Patient.

作者信息

Acosta Alejandro, Ramirez Marquez Estefania, Aguayo Angel, Perez Alejandro, Rivera Lília, Oliver Armando L

机构信息

Ophthalmology, University of Puerto Rico, Medical Sciences Campus, San Juan, USA.

Ophthalmology and Cornea, University of Puerto Rico, Medical Sciences Campus, San Juan, USA.

出版信息

Cureus. 2023 Oct 11;15(10):e46850. doi: 10.7759/cureus.46850. eCollection 2023 Oct.

DOI:10.7759/cureus.46850
PMID:37954775
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10637339/
Abstract

We report on a case study involving a 58-year-old male with a pigmented corneal ulcer. The patient presented with a two-month history of an unresolved corneal ulcer in the oculus sinister (OS), accompanied by increasing ocular discomfort. His best corrected visual acuity (BCVA) was 20/20 oculus dexter and hand motion OS. Examination of OS revealed mild conjunctival injection, diffuse corneal edema, and the presence of a central pigmented lesion. Microbiological analysis via culture identified the causative agent as Ochroconis fungi, belonging to the dematiaceous species. Subsequently, the patient's condition was managed through a comprehensive regimen that included multiple topical antifungal agents, a topical antibiotic, and povidone-iodine drops. After two months of treatment, the patient exhibited improvement in his condition. His BCVA improved to counting fingers at a distance of two feet OS.

摘要

我们报告了一例涉及一名58岁患有色素性角膜溃疡男性的病例研究。该患者左眼(OS)角膜溃疡未愈达两个月,伴有眼部不适加重。其右眼最佳矫正视力(BCVA)为20/20,左眼为手动视力。左眼检查显示轻度结膜充血、弥漫性角膜水肿以及中央色素性病变。通过培养进行的微生物分析确定病原体为暗色丝孢霉属真菌,属于暗色真菌类。随后,通过包括多种局部抗真菌药物、一种局部抗生素和聚维酮碘滴眼液的综合治疗方案对患者病情进行管理。经过两个月的治疗,患者病情有所改善。其左眼BCVA提高到在两英尺远处能数指。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fbfd/10637339/c82a1d585102/cureus-0015-00000046850-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fbfd/10637339/c82a1d585102/cureus-0015-00000046850-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fbfd/10637339/c82a1d585102/cureus-0015-00000046850-i01.jpg

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本文引用的文献

1
Pigmented Corneal Ulcer.色素性角膜溃疡
J Ophthalmic Vis Res. 2019 Oct 24;14(4):506-508. doi: 10.18502/jovr.v14i4.5461. eCollection 2019 Oct-Dec.
2
Diabetic complications and dysregulated innate immunity.糖尿病并发症与先天免疫失调
Front Biosci. 2008 Jan 1;13:1227-39. doi: 10.2741/2757.
3
Pigmented plaque presentation of dematiaceous fungal keratitis: a clinicopathologic correlation.暗色丝孢霉性角膜炎的色素斑块表现:临床病理相关性
Cornea. 2004 Aug;23(6):571-6. doi: 10.1097/01.ico.0000126318.90271.3c.
4
Spectrum of fungal keratitis at Wills Eye Hospital, Philadelphia, Pennsylvania.宾夕法尼亚州费城威尔斯眼科医院的真菌性角膜炎谱系
Cornea. 2000 May;19(3):307-12. doi: 10.1097/00003226-200005000-00010.
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Corneal ulcer caused by Bipolaris hawaiiensis.由夏威夷平脐蠕孢引起的角膜溃疡。
J Med Vet Mycol. 1988;26(5):301-6.