Huang Dong-Hui, Zhang Yi-Xiao, Wang Xiao-Bin, Sun Ming-Hui, Guo Ren-Hao, Leng Xu, Du Qiang, Chen Hong-Yu, Nan Yu-Xin, Wu Qi-Jun, Pan Bo-Chen, Zhao Yu-Hong
Department of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang, China.
Liaoning Key Laboratory of Precision Medical Research on Major Chronic Disease, Liaoning, China.
Hum Reprod Open. 2023 Oct 31;2023(4):hoad041. doi: 10.1093/hropen/hoad041. eCollection 2023.
Is dietary non-enzymatic antioxidant capacity related to semen quality?
The only statistically significant association of semen quality parameters with dietary total antioxidant capacity (DTAC) detected was an inverse association between DTAC and ejaculate volume.
Growing interest exists regarding the role of diet in influencing semen quality. While DTAC is linked to favorable health outcomes, its association with semen quality, especially among men attending infertility clinics, remains understudied.
This cross-sectional study was carried out between June and December of 2020. In total, 1715 participants were included in the final analysis.
PARTICIPANTS/MATERIALS SETTING METHODS: Men who attended an infertility clinic in China were enrolled. Experienced clinical technicians performed the semen analysis. The DTAC indices included the ferric-reducing ability of plasma, oxygen radical absorbance capacity, total reactive antioxidant potential, and Trolox equivalent antioxidant capacity. The quantile regression model was used for multivariate analysis.
After adjustment for a variety of confounding variables, a significant inverse association was identified between DTAC and ejaculate volume (β = -0.015, 95% CI = -0.023, -0.006, β = -0.193, 95% CI = -0.379, -0.006, = 0.007; β = -0.019, 95% CI = -0.041, 0.002, β = -0.291, 95% CI = -0.469, -0.112, = 0.002). The majority of DTAC indices have no statistically significant association with semen quality parameters.
We cannot infer causality because of the nature of the cross-sectional study design. The robustness of the conclusion may be compromised by the exactness of non-enzymatic antioxidant capacity estimation.
Our findings demonstrated no association between DTAC indices and semen quality parameters among men attending an infertility clinic, except for ejaculate volume. Even though our findings are mostly non-significant, they contribute novel knowledge to the field of study while also laying the groundwork for future well-designed studies.
STUDY FUNDING/COMPETING INTERESTS: This work was supported by the JieBangGuaShuai Project of Liaoning Province [grant number 2021JH1/10400050], the Clinical Research Cultivation Project of Shengjing Hospital [grant number M1590], and the Outstanding Scientific Fund of Shengjing Hospital [grant number M1150]. The sponsors had no role in study design, or in the collection, analysis, and interpretation of data, or in the writing of the report, or in the decision to submit the article for publication. There are no conflicts of interest to declare.
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饮食中的非酶抗氧化能力与精液质量有关吗？
检测到的精液质量参数与饮食总抗氧化能力（DTAC）之间唯一具有统计学意义的关联是DTAC与射精量之间呈负相关。
饮食在影响精液质量方面的作用越来越受到关注。虽然DTAC与良好的健康结果相关，但其与精液质量的关联，尤其是在不孕不育门诊就诊的男性中，仍未得到充分研究。
研究设计、规模、持续时间：这项横断面研究于2020年6月至12月进行。最终分析共纳入1715名参与者。
参与者/材料、设置、方法：招募在中国一家不孕不育门诊就诊的男性。经验丰富的临床技术人员进行精液分析。DTAC指标包括血浆铁还原能力、氧自由基吸收能力、总反应性抗氧化潜力和Trolox等效抗氧化能力。采用分位数回归模型进行多变量分析。
在对各种混杂变量进行调整后，发现DTAC与射精量之间存在显著负相关（β = -0.015，95%置信区间 = -0.023，-0.006，β = -0.193，95%置信区间 = -0.379，-0.006，P = 0.007；β = -0.019，95%置信区间 = -0.041，0.002，β = -0.291，95%置信区间 = -0.469，-0.112，P = 0.002）。大多数DTAC指标与精液质量参数无统计学意义的关联。
局限性、谨慎原因：由于横断面研究设计的性质，我们无法推断因果关系。非酶抗氧化能力估计的准确性可能会影响结论的稳健性。
我们的研究结果表明，在不孕不育门诊就诊的男性中，除射精量外，DTAC指标与精液质量参数之间无关联。尽管我们的研究结果大多无统计学意义，但它们为该研究领域贡献了新知识，同时也为未来精心设计的研究奠定了基础。
研究资金/利益冲突：这项工作得到了辽宁省揭榜挂帅项目[项目编号2021JH1/10400050]、盛京医院临床研究培育项目[项目编号M1590]和盛京医院杰出科学基金[项目编号M1150]的支持。资助者在研究设计、数据收集、分析和解释、报告撰写或提交文章发表的决策过程中均未发挥作用。不存在利益冲突需要声明。
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