Department of Pharmaceutical Engineering, College of Life Science & Technology, Heilongjiang Bayi Agricultural University, 5 Xinfeng Road, Daqing 163319, PR China.
Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, and School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang 110016, PR China.
Fitoterapia. 2024 Sep;177:106040. doi: 10.1016/j.fitote.2024.106040. Epub 2024 May 25.
Four new lignans named cephaliverins A-D (1-4), along with seven known analogues (5-11), were isolated from Cephalotaxus oliveri Mast. Their structures were elucidated on the basis of HR-ESI-MS and NMR analyses, and their absolute configurations were determined by ECD comparison. Cephaliverin A (1), herpetotriol (5) and hedyotol A (6) exhibited moderate antitumor activity against HepG2 and A549 cell lines.
从三尖杉属植物中分离得到了四个新的木脂素化合物 Cephaliverins A-D（1-4），以及七个已知类似物（5-11）。基于高分辨电喷雾质谱（HR-ESI-MS）和核磁共振分析（NMR）确定了它们的结构，并通过圆二色谱（ECD）比较确定了它们的绝对构型。Cephaliverin A（1）、海兔二醇（5）和山荷叶醇 A（6）对 HepG2 和 A549 细胞系表现出中等的抗肿瘤活性。
