Boot R, Walvoort H C
Lab Anim. 1986 Jul;20(3):242-8. doi: 10.1258/002367786780865601.
In the course of post-mortem examination of conventional random-bred and inbred (immunosuppressed) strain 2/N guineapigs kept in separate quarters, otitis media was diagnosed in 62 of 462 animals (13.4%) and 18 of 66 animals (27.3%) respectively. Clinical signs of otitis media were seen in only two random-bred animals but in nearly 50% of affected inbred animals. In random-bred guineapigs, purulent, often bilateral, otitis media was associated mainly with the isolation of Streptococcus zooepidemicus, Bordetella bronchiseptica, Pasteurella and Actinobacillus spp. and micrococci. In strain 2/N guineapigs serous or purulent often bilateral otitis media was associated mainly with the isolation of B. bronchiseptica and Pseudomonas aeruginosa serotypes 10 and 11. The simultaneous occurrence of similar pathogenic bacteria in both ears of bilaterally affected animals and in pneumonic lung tissue (in random-bred animals) suggested ascending and descending infection originating from the upper respiratory tract. It is concluded that otitis media, associated with the isolation of a variety of respiratory bacterial species, must be considered a major disease problem in guineapigs.
在对分别饲养在不同区域的常规随机繁殖和近交（免疫抑制）2/N品系豚鼠进行尸检的过程中，分别在462只动物中的62只（13.4%）和66只动物中的18只（27.3%）诊断出中耳炎。仅在两只随机繁殖的动物中观察到中耳炎的临床症状，但在近50%受影响的近交动物中观察到了该症状。在随机繁殖的豚鼠中，化脓性、通常为双侧性的中耳炎主要与兽疫链球菌、支气管败血波氏杆菌、巴氏杆菌和放线杆菌属以及微球菌的分离有关。在2/N品系豚鼠中，浆液性或化脓性、通常为双侧性的中耳炎主要与支气管败血波氏杆菌以及10型和11型铜绿假单胞菌的分离有关。在双侧患病动物的双耳以及（随机繁殖动物的）肺炎肺组织中同时出现相似的病原菌，提示感染是由上呼吸道上行和下行引起的。得出的结论是，与多种呼吸道细菌分离相关的中耳炎必须被视为豚鼠的一个主要疾病问题。
