Department of Gastroenterology, Hospital General de Tomelloso, Tomelloso, 13700 Ciudad Real, Spain.
Instituto de Investigación Sanitaria de Castilla-La Mancha (IDISCAM), 45004 Toledo, Spain.
Nutrients. 2023 Oct 24;15(21):4507. doi: 10.3390/nu15214507.
Non-alcoholic fatty liver disease (NAFLD) is a common concomitant condition in patients with inflammatory bowel disease (IBD). We aim to assess the magnitude of this association.
We searched MEDLINE, EMBASE and Scopus libraries for the period up to February 2023 to identify studies reporting cohorts of IBD patients in which NALFLD was evaluated.
Eighty-nine studies were analyzed. The overall prevalence of NAFLD was 24.4% (95%CI, 19.3-29.8) in IBD, 20.2% (18.3-22.3) in Crohn's disease and 18.5% (16.4-20.8) for ulcerative colitis. Higher prevalence was found in male compared to female patients, in full papers compared to abstracts, and in cross-sectional studies compared to prospective and retrospective ones. The prevalence of NAFLD in IBD has increased in studies published from 2015 onwards: 23.2% (21.5-24.9) vs. 17.8% (13.2-22.9). Diagnostic methods for NAFLD determined prevalence figures, being highest in patients assessed by controlled attenuation parameter (38.8%; 33.1-44.7) compared to ultrasonography (28.5%; 23.1-34.2) or other methods. The overall prevalence of fibrosis was 16.7% (12.2-21.7) but varied greatly according to the measurement method.
One-quarter of patients with IBD might present with NAFLD worldwide. This proportion was higher in recent studies and in those that used current diagnostic methods.
非酒精性脂肪性肝病（NAFLD）是炎症性肠病（IBD）患者常见的合并症。我们旨在评估这种关联的程度。
我们检索了 MEDLINE、EMBASE 和 Scopus 数据库，以确定在报道评估 IBD 患者队列的研究中，有哪些研究报告了 NAFLD。
分析了 89 项研究。IBD 患者的总体 NAFLD 患病率为 24.4%（95%CI，19.3-29.8），克罗恩病为 20.2%（18.3-22.3），溃疡性结肠炎为 18.5%（16.4-20.8）。与女性患者相比，男性患者的患病率更高，全文报告比摘要报告更高，横断面研究比前瞻性和回顾性研究更高。自 2015 年以来发表的研究中，IBD 患者的 NAFLD 患病率有所增加：23.2%（21.5-24.9）vs. 17.8%（13.2-22.9）。NAFLD 的诊断方法决定了患病率数据，通过受控衰减参数评估的患者患病率最高（38.8%；33.1-44.7），其次是超声检查（28.5%；23.1-34.2）或其他方法。纤维化的总体患病率为 16.7%（12.2-21.7），但根据测量方法的不同而有很大差异。
全球范围内，四分之一的 IBD 患者可能患有 NAFLD。在最近的研究和使用当前诊断方法的研究中，这一比例更高。
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