溶酶体 pH 值的起伏：LAMP 蛋白的矛盾作用？
Ups and downs of lysosomal pH: conflicting roles of LAMP proteins?
机构信息
Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, New York, NY, USA.
Roy J. Carver Department of Biochemistry, Biophysics and Molecular Biology, Iowa State University, Ames, IA, USA.
出版信息
Autophagy. 2024 Feb;20(2):437-440. doi: 10.1080/15548627.2023.2274253. Epub 2024 Jan 25.
Abstract
The acidic pH of lysosomes is critical for catabolism in eukaryotic cells and is altered in neurodegenerative disease including Alzheimer and Parkinson. Recent reports using Drosophila and mammalian cell culture systems have identified novel and, at first sight, conflicting roles for the lysosomal associated membrane proteins (LAMPs) in the regulation of the endolysosomal system. AD: Alzheimer disease; LAMP: lysosomal associated membrane protein; LTR: LysoTracker; PD: Parkinson disease; TMEM175: transmembrane protein 175; V-ATPase: vacuolar-type H-translocating ATPase.
摘要
溶酶体的酸性 pH 对真核细胞的分解代谢至关重要，在包括阿尔茨海默病和帕金森病在内的神经退行性疾病中发生改变。最近使用果蝇和哺乳动物细胞培养系统的报告确定了溶酶体相关膜蛋白 (LAMP) 在调节内溶酶体系统中的新的、乍一看相互矛盾的作用。AD：阿尔茨海默病；LAMP：溶酶体相关膜蛋白；LTR：LysoTracker；PD：帕金森病；TMEM175：跨膜蛋白 175；V-ATPase：液泡型 H-转运 ATP 酶。
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