van Veen L C, Teng C, Hay W W, Meschia G, Battaglia F C
Metabolism. 1987 Jan;36(1):48-53. doi: 10.1016/0026-0495(87)90062-x.
To verify previous indirect evidence suggesting an important role of amino acids as substrates of fetal oxidative metabolism, leucine disposal and oxidation rates were measured in chronically catheterized fetal lambs during the last month of gestation. Under normal physiologic conditions the leucine oxidation rates were 6.43 +/- 1.02 mumol min-1 for fetuses with an average weight of 3.22 +/- 0.07 kg and comparable in magnitude to the fetal rate of leucine accretion. In seven animals studied before and during fasting, the fetal leucine oxidation rate increased with fasting from 5.8 +/- 1.0 to 10.8 +/- 1.3 mumol min-1. These data demonstrate that there is rapid oxidative degradation of leucine by the fetus and that the rate of this process increases in response to maternal fasting.
为了验证先前的间接证据，这些证据表明氨基酸作为胎儿氧化代谢底物具有重要作用，在妊娠最后一个月，对长期插管的胎羊的亮氨酸处理和氧化速率进行了测量。在正常生理条件下，平均体重为3.22±0.07千克的胎儿的亮氨酸氧化速率为6.43±1.02微摩尔/分钟，其幅度与胎儿亮氨酸积累速率相当。在七只在禁食前和禁食期间进行研究的动物中，胎儿亮氨酸氧化速率随禁食从5.8±1.0增加到10.8±1.3微摩尔/分钟。这些数据表明，胎儿会快速氧化降解亮氨酸，并且这一过程的速率会因母体禁食而增加。
