Department of Molecular Biology and Genetics, Muş Alparslan University, Muş, Turkey.
Department of Food Quality Control and Analysis, Muş Alparslan University, Muş, Turkey.
J Gastroenterol Hepatol. 2023 Dec;38(12):2142-2151. doi: 10.1111/jgh.16395. Epub 2023 Nov 14.
The liver plays a critical role in metabolic homeostasis, and its health is often compromised by poor dietary habits. This study aimed to investigate the therapeutic potential of SCD Probiotics in mitigating adverse liver effects induced by a cafeteria diet in male Wistar rats during their developmental period.
Four groups of seven male Wistar rats each were subjected to different dietary regimens from day 21 (weaning) to day 56. The groups were as follows: a control group on normal feed; a probiotic-supplemented group on normal feed; a group on a cafeteria diet mixed with normal feed; and a group on a cafeteria diet mixed with normal feed, supplemented with SCD Probiotics. Liver health was assessed using Fourier transform infrared spectroscopy and histopathological evaluations.
Rats on the cafeteria diet exhibited significant disruptions in lipid, protein, cholesterol, triglyceride levels, and glycogen/phosphate content. Histopathological abnormalities such as lymphocytic infiltration, steatosis, and necrosis were also observed. However, SCD Probiotics supplementation led to notable improvements in the liver's biomolecular composition and mitigated histopathological abnormalities. Serum liver enzyme levels (AST, ALT, ALP, and LDH) also showed beneficial effects, while serum albumin levels remained stable.
SCD Probiotics demonstrated a promising potential to counteract the adverse liver effects induced by a cafeteria diet in male Wistar rats. The study revealed significant improvements in biomolecular composition, histopathology, and serum enzyme levels. However, these findings are preliminary and necessitate further in vivo studies and clinical trials for validation.
肝脏在代谢稳态中起着关键作用，其健康常常因不良饮食习惯而受损。本研究旨在探讨 SCD 益生菌在缓解雄性 Wistar 大鼠发育期间 cafeteria 饮食引起的不良肝脏影响方面的治疗潜力。
从第 21 天（断奶）到第 56 天，4 组 7 只雄性 Wistar 大鼠分别接受不同的饮食方案。各组如下：正常饲料对照组；正常饲料添加益生菌组；正常饲料混合 cafeteria 饮食组；正常饲料混合 cafeteria 饮食添加 SCD 益生菌组。采用傅里叶变换红外光谱和组织病理学评估来评估肝脏健康。
cafeteria 饮食组的大鼠表现出脂质、蛋白质、胆固醇、甘油三酯水平以及糖原/磷酸盐含量的显著紊乱。还观察到淋巴细胞浸润、脂肪变性和坏死等组织病理学异常。然而，SCD 益生菌补充剂导致肝脏生物分子组成的显著改善，并减轻了组织病理学异常。血清肝酶水平（AST、ALT、ALP 和 LDH）也表现出有益的影响，而血清白蛋白水平保持稳定。
SCD 益生菌显示出在雄性 Wistar 大鼠中对抗 cafeteria 饮食引起的不良肝脏影响的有前途的潜力。研究揭示了生物分子组成、组织病理学和血清酶水平的显著改善。然而，这些发现是初步的，需要进一步的体内研究和临床试验来验证。
