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红细胞、血小板和血浆在分支处相分离的理论模型

Theoretical model of phase separation of erythrocytes, platelets, and plasma at branches.

作者信息

Perkkiö J, Hokkanen J, Keskinen R

出版信息

Med Phys. 1986 Nov-Dec;13(6):882-6. doi: 10.1118/1.595813.

DOI:10.1118/1.595813
PMID:3796486
Abstract

Analytical expressions for the changes of the erythrocyte and platelet concentration are calculated as blood flows through a single bifurcation. The effect of the separation surface, which divides the blood into the two daughter vessels, upon the concentration changes is studied. Numerical fitting to the experimental data shows that both the erythrocyte and platelet distributions across the vessel are nonuniform. The maximum of the erythrocyte concentration is in the core, and of the platelet concentration, in the vicinity of the wall. A separation surface that is convex towards the axis of the vessel yields better fit to the experimental data than a concave one. Together with other studies, this suggests that flow-divider geometry depends on flow conditions and the vessel diameters. The results can be used for estimation of the distribution of erythrocytes and platelets in the microvasculature.

摘要

计算了血液流经单个分支时红细胞和血小板浓度变化的解析表达式。研究了将血液分成两个子血管的分隔面对浓度变化的影响。对实验数据的数值拟合表明,血管内红细胞和血小板的分布都是不均匀的。红细胞浓度最大值在核心区域,而血小板浓度最大值在壁面附近。朝向血管轴线凸出的分隔面比凹面更符合实验数据。与其他研究一起,这表明分流器的几何形状取决于流动条件和血管直径。这些结果可用于估计微脉管系统中红细胞和血小板的分布。

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