胃肠道间质瘤相关性高钙血症。
Gastrointestinal stromal tumour-induced hypercalcaemia.
机构信息
Internal Medicine, NHS Greater Glasgow and Clyde, Glasgow, UK
Medical Oncology, Beatson West of Scotland Cancer Centre, Glasgow, UK.
出版信息
BMJ Case Rep. 2023 Nov 15;16(11):e243613. doi: 10.1136/bcr-2021-243613.
Hypercalcaemia is recognised as the most common oncological metabolic emergency, with several proposed underlying mechanisms. Nevertheless, hypercalcaemia has been rarely reported as a complication in patients with gastrointestinal stromal tumours (GISTs). GISTs are uncommon mesenchymal tumours of the gastrointestinal tract. There are only nine previous cases of hypercalcaemia occurring in patients with GIST reported in the literature. We report a case of a man in his 70s with a background of metastatic GIST on fourth-line treatment. The patient presented with new hypercalcaemia and acute kidney injury. Despite medical management, his calcium remained elevated and he deteriorated secondary to significant disease progression.
高钙血症被认为是最常见的肿瘤代谢急症，其发病机制有多种学说。然而，胃肠道间质瘤（GIST）患者并发高钙血症的情况却很少见。GIST 是胃肠道的一种少见的间叶性肿瘤。文献中仅有 9 例 GIST 患者发生高钙血症的既往病例报道。我们报告了 1 例 70 多岁的男性患者，其患有转移性 GIST，处于四线治疗阶段。该患者出现新发高钙血症和急性肾损伤。尽管进行了药物治疗，但他的血钙仍居高不下，由于疾病显著进展，他的病情恶化。
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