School of Veterinary Medicine, Kitasato University, Aomori, Japan.
J Vet Med Sci. 2024 Jan 26;86(1):111-115. doi: 10.1292/jvms.23-0247. Epub 2023 Nov 14.
Primary cardiac tumors in animals are very rare. The purpose of this report was to describe the first case of a cardiac tumor comprising a malignant peripheral nerve sheath tumor and spontaneous atrial osseous metaplasia in a Corriedale sheep. Histologically, the tumor in the bilateral atrial pericardium consisted of dense cellular components comprising tumor cells and a sparse cellular area, and non-neoplastic mature bone tissue. The tumor cells were spindle-shaped, round, or polygonal, and proliferating, with fascicular, storiform, palisading, and sheet patterns. Immunohistochemically, the tumor cells were positive for vimentin, S-100, occasionally positive for myeline basic protein, glial fibrillary acidic protein, neurofilament, neuron specific enolase, and neuron growth factor receptor suggesting that they originated from the nervous system. On the basis of these findings, the final diagnosis was a malignant peripheral nerve sheath tumor and spontaneous atrial osseous metaplasia.
动物的原发性心脏肿瘤非常罕见。本报告的目的是描述首例在科里代尔羊中发生的心脏肿瘤，该肿瘤由恶性外周神经鞘瘤和自发性心房骨化生组成。组织学上，双侧心房心包内的肿瘤由密集的细胞成分组成，包括肿瘤细胞和稀疏的细胞区以及非肿瘤性成熟骨组织。肿瘤细胞呈梭形、圆形或多边形，呈束状、席纹状、栅栏状和片状生长。免疫组织化学染色显示，肿瘤细胞表达波形蛋白、S-100，偶尔表达髓磷脂碱性蛋白、神经胶质纤维酸性蛋白、神经丝、神经元特异性烯醇化酶和神经元生长因子受体，提示其起源于神经系统。基于这些发现，最终诊断为恶性外周神经鞘瘤和自发性心房骨化生。
