Laboratory of Veterinary Pathology, School of Veterinary Medicine, Azabu University, 1-17-71 Fuchinobe Chuo, Sagamihara, Kanagawa 229-8501, Japan.
Vet Pathol. 2010 Sep;47(5):923-30. doi: 10.1177/0300985810375055. Epub 2010 Jun 23.
A retrospective study was performed on primary cardiac tumors found in 44 cattle during meat inspection in Japan, using histology, immunohistochemistry, and electron microscopy. The age of affected cattle ranged from 10 to 129 months; 82% were less than 3 years old. In 38 hearts, the tumor was solitary; the remaining 6 hearts had multiple masses. All tumors were subendocardial and involved the papillary muscles and/or cardiac valves. Two histologic patterns were recognized; both included giant cells. Pattern 1 was characterized by interlacing fascicles of spindle-shaped cells; pattern 2 resembled cavernous hemangioma. The 2 patterns coexisted and were linked by transitional zones. Given the immunohistochemical reactivity and ultrastructure, the spindle-shaped cells were identified as smooth muscle cells and the giant cells as endothelial cells. Single cell and multicellular angiogenesis by giant cells was observed. The tumors were classified as cardiac angioleiomyoma. Subendocardial multipotential mesenchymal cells, persistent tissue of the endocardial cushion, or valvular interstitial cells were suspected as the origin.
对日本肉类检查中发现的 44 头牛的原发性心脏肿瘤进行了回顾性研究，使用组织学、免疫组织化学和电子显微镜。受影响牛的年龄为 10 至 129 个月；82%小于 3 岁。38 颗心脏中的肿瘤为单发；其余 6 颗心脏有多发性肿块。所有肿瘤均位于心内膜下，累及乳头肌和/或心瓣膜。识别出两种组织学模式；两者均包括巨细胞。模式 1 的特征是交织的梭形细胞束；模式 2 类似于海绵状血管瘤。两种模式共存，并通过过渡区相连。鉴于免疫组织化学反应性和超微结构，梭形细胞被鉴定为平滑肌细胞，巨细胞被鉴定为内皮细胞。观察到巨细胞的单细胞和多细胞血管生成。肿瘤被分类为心脏血管平滑肌瘤。心内膜垫的多能间充质细胞、残余组织或瓣膜间质细胞被怀疑是起源。
