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早产儿念珠菌血症:一项回顾性单中心研究。

candidaemia in premature infants: a retrospective single-centre study.

机构信息

The Seventh Medical Centre of Chinese PLA General Hospital, Beijing, China.

Faculty of Pediatrics, the Chinese PLA General Hospital, Beijing, China.

出版信息

BMJ Paediatr Open. 2023 Nov;7(1). doi: 10.1136/bmjpo-2023-002245.

DOI:10.1136/bmjpo-2023-002245
PMID:37968014
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10660911/
Abstract

This retrospective study was conducted in a neonatal intensive care unit in Beijing. Patients whose blood culture yielded during hospitalisation from January 2009 to December 2017 were enrolled. Thirteen preterm infants of median gestational age 29.85 weeks were included. Laboratory tests on the day of onset showed thrombocytopaenia in 11 patients, granulocytopaenia in eight and elevated C-reactive protein in seven. No fungal endophthalmitis, renal infection, carditis or involvement of other end organs was observed in any of the cases. All 13 patients were cured after fluconazole therapy.

摘要

本回顾性研究在北京的一家新生儿重症监护病房进行。入选的患者为 2009 年 1 月至 2017 年 12 月住院期间血培养阳性的患者。共纳入 13 例胎龄中位数为 29.85 周的早产儿。发病当天的实验室检查显示 11 例血小板减少,8 例粒细胞减少,7 例 C 反应蛋白升高。所有病例均未见真菌性眼内炎、肾感染、心内膜炎或其他终末器官受累。氟康唑治疗后,13 例患者均治愈。

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Curr Med Mycol. 2024 Feb 1;10. doi: 10.22034/cmm.2024.345248.1565. eCollection 2024.

本文引用的文献

1
Candidemia and Invasive Candidiasis.念珠菌血症和侵袭性念珠菌病。
Infect Dis Clin North Am. 2021 Jun;35(2):389-413. doi: 10.1016/j.idc.2021.03.007.
2
Candida utilis fungaemia following endoscopic intervention on ureteral stent in a kidney transplant recipient: Case report and a review of the literature.肾移植受者在接受输尿管支架内镜干预后发生的利用假丝酵母菌菌血症:病例报告及文献复习。
Mycoses. 2018 Aug;61(8):594-599. doi: 10.1111/myc.12766. Epub 2018 Jun 11.
3
Prevention and treatment of neonatal nosocomial infections.新生儿医院感染的预防与治疗
Matern Health Neonatol Perinatol. 2017 Feb 13;3:5. doi: 10.1186/s40748-017-0043-3. eCollection 2017.
4
Candida utilis candidaemia in neonatal patients.新生患儿中利用假丝酵母菌引起的败血症。
J Med Microbiol. 2011 Jun;60(Pt 6):838-841. doi: 10.1099/jmm.0.023408-0. Epub 2011 Feb 24.
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Clinical microbiology of bacterial and fungal sepsis in very-low-birth-weight infants.极低出生体重儿细菌性和真菌性败血症的临床微生物学
Clin Microbiol Rev. 2004 Jul;17(3):638-80, table of contents. doi: 10.1128/CMR.17.3.638-680.2004.
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Candidemia in a neonatal intensive care unit: trends during fifteen years and clinical features of 111 cases.新生儿重症监护病房的念珠菌血症:15年趋势及111例临床特征
Pediatr Infect Dis J. 1998 Jun;17(6):504-8. doi: 10.1097/00006454-199806000-00014.