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Outcomes of t(11;14) light chain (AL) amyloidosis after autologous stem cell transplantation: benchmark for new therapies.

作者信息

Bal Susan, Estrada-Merly Noel, Costa Luciano J, Qazilbash Muzaffar H, Kumar Shaji, D'Souza Anita

机构信息

Division of Hematology/Oncology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.

Division of Hematology/Oncology, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA.

出版信息

Blood Cancer J. 2023 Nov 15;13(1):170. doi: 10.1038/s41408-023-00945-0.

DOI:10.1038/s41408-023-00945-0
PMID:37968258
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10651880/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf51/10651880/f85cc6e94fdf/41408_2023_945_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf51/10651880/f85cc6e94fdf/41408_2023_945_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf51/10651880/f85cc6e94fdf/41408_2023_945_Fig1_HTML.jpg

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Outcomes of t(11;14) light chain (AL) amyloidosis after autologous stem cell transplantation: benchmark for new therapies.自体干细胞移植后t(11;14)轻链(AL)淀粉样变性的预后:新疗法的基准
Blood Cancer J. 2023 Nov 15;13(1):170. doi: 10.1038/s41408-023-00945-0.
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High-Dose Melphalan and Autologous Peripheral Blood Stem Cell Transplantation in AL Amyloidosis.高剂量美法仑和自体外周血造血干细胞移植治疗 AL 淀粉样变性。
Acta Haematol. 2020;143(4):381-387. doi: 10.1159/000506498. Epub 2020 Apr 3.
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Early serum free light chain response after high-dose melphalan and stem cell transplantation predicts hematologic response in AL amyloidosis.大剂量美法仑和干细胞移植后早期血清游离轻链反应可预测AL淀粉样变性的血液学反应。
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Modified High-Dose Melphalan and Autologous Stem Cell Transplantation for Immunoglobulin Light Chain Amyloidosis.改良大剂量马法兰和自体干细胞移植治疗免疫球蛋白轻链淀粉样变性。
Biol Blood Marrow Transplant. 2018 Sep;24(9):1823-1827. doi: 10.1016/j.bbmt.2018.06.018. Epub 2018 Jun 20.
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Stem Cell Mobilization and Autologous Transplant for Immunoglobulin Light-Chain Amyloidosis.干细胞动员和自体移植治疗免疫球蛋白轻链淀粉样变性。
Hematol Oncol Clin North Am. 2020 Dec;34(6):1133-1144. doi: 10.1016/j.hoc.2020.07.007. Epub 2020 Sep 12.
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Venetoclax Plus CyBorD Induction Therapy and Venetoclax Maintenance Treatment for Immunoglobulin Light Chain Amyloidosis with t(11;14) Translocation.维奈托克联合CyBorD诱导疗法及维奈托克维持治疗伴t(11;14)易位的免疫球蛋白轻链淀粉样变性
Curr Oncol. 2025 Jan 26;32(2):63. doi: 10.3390/curroncol32020063.
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J Clin Med. 2024 Mar 18;13(6):1744. doi: 10.3390/jcm13061744.

本文引用的文献

1
Impact of cytogenetic abnormalities on treatment outcomes in patients with amyloid light-chain amyloidosis: subanalyses from the ANDROMEDA study.细胞遗传学异常对淀粉样轻链淀粉样变性患者治疗结局的影响:来自 ANDROMEDA 研究的亚分析。
Amyloid. 2023 Sep;30(3):268-278. doi: 10.1080/13506129.2022.2164488. Epub 2023 Feb 13.
2
Daratumumab-Based Treatment for Immunoglobulin Light-Chain Amyloidosis.达雷妥尤单抗治疗免疫球蛋白轻链淀粉样变性。
N Engl J Med. 2021 Jul 1;385(1):46-58. doi: 10.1056/NEJMoa2028631.
3
Bortezomib-Based Induction Is Associated with Superior Outcomes in Light Chain Amyloidosis Patients Treated with Autologous Hematopoietic Cell Transplantation Regardless of Plasma Cell Burden.
无论浆细胞负荷如何,基于硼替佐米的诱导治疗与接受自体造血细胞移植的轻链淀粉样变性患者的更好预后相关。
Transplant Cell Ther. 2021 Mar;27(3):264.e1-264.e7. doi: 10.1016/j.jtct.2020.11.018. Epub 2020 Dec 16.
4
Venetoclax induces deep hematologic remissions in t(11;14) relapsed/refractory AL amyloidosis.维奈托克可诱导 t(11;14)复发/难治性 AL 淀粉样变性的深度血液学缓解。
Blood Cancer J. 2021 Jan 11;11(1):10. doi: 10.1038/s41408-020-00397-w.
5
Venetoclax for the treatment of translocation (11;14) AL amyloidosis.维奈托克用于治疗11号与14号染色体易位的AL型淀粉样变性。
Blood Cancer J. 2020 May 11;10(5):55. doi: 10.1038/s41408-020-0321-6.
6
Interphase fluorescence in situ hybridization in untreated AL amyloidosis has an independent prognostic impact by abnormality type and treatment category.未经治疗的 AL 淀粉样变性中间期荧光原位杂交的异常类型和治疗类别具有独立的预后影响。
Leukemia. 2017 Jul;31(7):1562-1569. doi: 10.1038/leu.2016.369. Epub 2016 Dec 1.
7
Prognostic impact of cytogenetic aberrations in AL amyloidosis patients after high-dose melphalan: a long-term follow-up study.高剂量美法仑治疗后 AL 淀粉样变性患者细胞遗传学异常的预后影响:一项长期随访研究。
Blood. 2016 Jul 28;128(4):594-602. doi: 10.1182/blood-2015-10-676361. Epub 2016 Jun 2.
8
Improved Outcomes After Autologous Hematopoietic Cell Transplantation for Light Chain Amyloidosis: A Center for International Blood and Marrow Transplant Research Study.自体造血细胞移植治疗轻链淀粉样变性后改善的预后:一项国际血液和骨髓移植研究中心的研究
J Clin Oncol. 2015 Nov 10;33(32):3741-9. doi: 10.1200/JCO.2015.62.4015. Epub 2015 Sep 14.
9
Abnormal FISH in patients with immunoglobulin light chain amyloidosis is a risk factor for cardiac involvement and for death.免疫球蛋白轻链淀粉样变性患者的异常荧光原位杂交是心脏受累和死亡的危险因素。
Blood Cancer J. 2015 May 1;5(5):e310. doi: 10.1038/bcj.2015.34.
10
Translocation t(11;14) is associated with adverse outcome in patients with newly diagnosed AL amyloidosis when treated with bortezomib-based regimens.易位 t(11;14)与硼替佐米为基础的方案治疗新诊断的 AL 淀粉样变性患者的不良预后相关。
J Clin Oncol. 2015 Apr 20;33(12):1371-8. doi: 10.1200/JCO.2014.57.4947. Epub 2015 Mar 16.