干细胞动员和自体移植治疗免疫球蛋白轻链淀粉样变性。
Stem Cell Mobilization and Autologous Transplant for Immunoglobulin Light-Chain Amyloidosis.
机构信息
Division of Hematology, Mayo Clinic, 200 Southwest First Street, W10, Rochester, MN 55905, USA.
Department of Internal Medicine V, Division of Hematology/Oncology, Amyloidosis Center, Heidelberg University Hospital, Im Neuenheimer Feld 450, Heidelberg 69120, Germany.
出版信息
Hematol Oncol Clin North Am. 2020 Dec;34(6):1133-1144. doi: 10.1016/j.hoc.2020.07.007. Epub 2020 Sep 12.
Abstract
Stem cell transplantation was one of the first proven effective regimens for the management of immunoglobulin light-chain amyloidosis. Criteria for patient selection and the mobilization regimen become important features in ensuring a safe outcome. The technique of stem cell transplantation has evolved considerably in parallel with the development of new chemotherapeutic agents for the management of amyloidosis. Optimal outcomes require both the use of effective novel agent induction and appropriate application of high-dose chemotherapy with subsequent stem cell reconstitution.
摘要
干细胞移植是治疗免疫球蛋白轻链淀粉样变性的首批被证实有效的方案之一。患者选择标准和动员方案是确保安全结果的重要特征。随着新型治疗淀粉样变性药物的发展，干细胞移植技术也得到了相当大的发展。最佳结果需要有效新型药物诱导和随后高剂量化疗及干细胞重建的适当应用。
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