Andrejkovits Ákos Vince, Huțanu Adina, Susányi Ervin József, Negrea Valentina, Văsieșiu Anca Meda
Doctoral School of Medicine and Pharmacy, I.O.S.U.D., George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, Romania.
Department of Laboratory Medicine, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, Romania.
J Crit Care Med (Targu Mures). 2023 Nov 14;9(4):208-217. doi: 10.2478/jccm-2023-0025. eCollection 2023 Oct.
The severity of COVID-19 relies on several factors, but the overproduction of pro-inflammatory cytokines remains a central mechanism. The aim of this study was to investigate the predictive utility of interleukin (IL)-6, IL-8, IL-10, IL-12, tumor necrosis factor alpha (TNF-α), and interferon gamma (IFN-γ) measurement in patients with COVID-19.
We prospectively enrolled 181 adult patients with COVID-19 admitted to the 1 Infectious Disease County Hospital Târgu Mureș from December 2020 to September 2021. Serum cytokine levels were measured and correlated with disease severity, need for oxygen therapy, intensive care unit (ICU) transfer, and outcome.
We found significantly higher serum levels of IL-6, IL-8, and IL-10 in patients with severe COVID-19 and in those with a fatal outcome. The logistic regression analysis showed a significant predictive value for IL-8 regarding disease severity, and for IL6 and IL-10 regarding ICU transfer and fatal outcome.
Serum levels of IL-6, IL-8, and IL-10 were significantly increased in patients with COVID-19, but their predictive value regarding disease severity and the need for oxygen therapy was poor. We found IL-6 and IL-10 to have a good predictive performance regarding ICU transfer and fatal outcome.
新型冠状病毒肺炎（COVID-19）的严重程度取决于多种因素，但促炎细胞因子的过度产生仍然是核心机制。本研究的目的是探讨白细胞介素（IL）-6、IL-8、IL-10、IL-12、肿瘤坏死因子α（TNF-α）和干扰素γ（IFN-γ）检测对COVID-19患者的预测效用。
我们前瞻性纳入了2020年12月至2021年9月在特尔古穆列什县第一传染病医院住院的181例成年COVID-19患者。检测血清细胞因子水平，并将其与疾病严重程度、氧疗需求、重症监护病房（ICU）转诊及预后相关联。
我们发现重症COVID-19患者及死亡患者的血清IL-6、IL-8和IL-10水平显著更高。逻辑回归分析显示，IL-8对疾病严重程度具有显著预测价值，IL-6和IL-10对ICU转诊和死亡结局具有显著预测价值。
COVID-19患者的血清IL-6、IL-8和IL-10水平显著升高，但其对疾病严重程度和氧疗需求的预测价值较差。我们发现IL-6和IL-10对ICU转诊和死亡结局具有良好的预测性能。
