Dehghan Ali, Soltani Hamidreza, Faezi Seyedeh Tahereh, Baghdadi Azarakhsh, Soleymani Salehabadi Hossein, Bashiri Hamidreza, Hemayati Roya, Mansouri Mehrdad, Motaghi Mohammad, Nejadhosseinian Mohammad
Rheumatology Research Center, Tehran University of Medical Sciences, Iran.
Department of Internal Medicine, Rheumatology, Shahid Sadoughi Hospital, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Reumatologia. 2023;61(5):368-374. doi: 10.5114/reum/168396. Epub 2023 Sep 27.
Systemic lupus erythematosus (SLE) is a multisystem disorder that can affect multiple organs; psychiatric manifestations including depression and anxiety are commonly seen in SLE. The aim of this study is to explore the prevalence of depression, anxiety, and stress, and assess the quality of life (QOL) in patients with SLE and also evaluate associated risk factors.
In this cross-sectional study, adult patients with SLE were identified through our institution's SLE data registry. Participants were evaluated with three questionnaires: Depression, Anxiety, and Stress Scale (DASS-42), General Health Ouestionnaire-28 (GHQ-28), and World Health Organization quality of life instrument short form (WHO-QOL BREF).
A total of 222 patients were included in the study, 203 (91%) of whom were female and 19 were male (9%). Participants had a mean age of 35.6 ±9.5 years. According to DASS-42 questionnaire, 22.1%, 28.7% and 20.3% of patients had varying degrees of depression, anxiety, and stress, respectively. Based on GHQ-28 questionnaire, 137 (62%) of patients reported some degree of distress. Quality of life score was 12.8, 13, 14.3, and 13.9 in physical health, psychological health, social relationships, and environmental health, respectively.
We found that depression, anxiety, and stress are common in patients with SLE, and quality of life is significantly affected. A high percentage of patients with SLE deal with some degree of distress. Routine evaluation of the quality of life and psychological disturbances is recommended in patients with SLE. Non-pharmacological interventions as well as specialist referral should be considered in patients with anxiety, depression, or stress.
系统性红斑狼疮（SLE）是一种可累及多个器官的多系统疾病；包括抑郁和焦虑在内的精神症状在SLE患者中很常见。本研究的目的是探讨抑郁、焦虑和压力的患病率，评估SLE患者的生活质量（QOL），并评估相关危险因素。
在这项横断面研究中，通过本机构的SLE数据登记处确定成年SLE患者。参与者使用三份问卷进行评估：抑郁、焦虑和压力量表（DASS-42）、一般健康问卷-28（GHQ-28）和世界卫生组织生活质量简表（WHO-QOL BREF）。
本研究共纳入222例患者，其中203例（91%）为女性，19例为男性（9%）。参与者的平均年龄为35.6±9.5岁。根据DASS-42问卷，分别有22.1%、28.7%和20.3%的患者有不同程度的抑郁、焦虑和压力。根据GHQ-28问卷，137例（62%）患者报告有一定程度的痛苦。身体健康、心理健康、社会关系和环境健康方面的生活质量得分分别为12.8、13、14.3和13.9。
我们发现抑郁、焦虑和压力在SLE患者中很常见，生活质量受到显著影响。高比例的SLE患者有一定程度的痛苦。建议对SLE患者进行生活质量和心理障碍的常规评估。对于有焦虑、抑郁或压力的患者，应考虑非药物干预以及转诊至专科医生处。
