Gu M, Cheng Q, Wang X, Yuan F, Sam N B, Pan H, Li B, Ye D
1 Department of Epidemiology and Biostatistics, Anhui Medical University, Hefei, China.
2 Anhui Province Key Laboratory of Major Autoimmune Disease, Hefei, China.
Lupus. 2019 Mar;28(3):371-382. doi: 10.1177/0961203319828519.
To evaluate the impact of systemic lupus erythematosus (SLE) on health-related quality of life (HRQoL) assessed with SF-36 and explore factors associated with HRQoL in SLE patients.
A random-effect meta-analysis was performed to calculate extracted data. Sensitivity and subgroup analyses were performed to distinguish sources of heterogeneity.
A total of 36 articles were finally included in this meta-analysis, including 6510 patients. The pooled mean scores of SF-36 physical component summary and mental component summary were 46.10 (95% confidence interval (CI): 43.09-49.10) and 50.37 (95% CI: 47.78-52.87), respectively. Spearman's correlation analysis found that mean age, proportion of female participants, and publication decades were negatively associated with some of the SF-36 domains. Sample size and SLEDAI were positively associated with some of the SF-36 domains. Patients with SLE have lower HRQoL in comparison to the general population.
SLE has a significant impact on HRQoL, which proves that the necessity of improving HRQoL in SLE patients cannot be ignored. Measuring HRQoL should be considered as an indispensable part of the overall evaluation of health conditions of SLE patients.
评估系统性红斑狼疮（SLE）对采用SF-36评估的健康相关生活质量（HRQoL）的影响，并探讨SLE患者中与HRQoL相关的因素。
进行随机效应荟萃分析以计算提取的数据。进行敏感性和亚组分析以区分异质性来源。
本荟萃分析最终纳入36篇文章，包括6510例患者。SF-36身体成分总结和心理成分总结的合并平均得分分别为46.10（95%置信区间（CI）：43.09 - 49.10）和50.37（95%CI：47.78 - 52.87）。Spearman相关性分析发现，平均年龄、女性参与者比例和发表年代与部分SF-36领域呈负相关。样本量和SLE疾病活动指数（SLEDAI）与部分SF-36领域呈正相关。与一般人群相比，SLE患者的HRQoL较低。
SLE对HRQoL有显著影响，这证明改善SLE患者HRQoL的必要性不容忽视。测量HRQoL应被视为SLE患者健康状况总体评估中不可或缺的一部分。
