Programa de Doctorado en Ciencias Biomédicas, Universidad Nacional Autónoma de México (UNAM), México, Ciudad de México, México.
Unidad de Genética de la Nutrición, Depto. de Biología Molecular y Biotecnología, Instituto de Investigaciones Biomédicas, UNAM e Instituto Nacional de Pediatría, México, Ciudad de México, México.
PLoS One. 2018 Jul 10;13(7):e0199888. doi: 10.1371/journal.pone.0199888. eCollection 2018.
High-glycemic-index diets, as well as a sedentary lifestyle are considered as determinant factors for the development of obesity, type 2 diabetes, and cardiovascular diseases in humans. These diets have been shown to shorten the life span of C. elegans in a manner that is dependent on insulin signaling, but the participation of other signaling pathways have not been addressed. In this study, we have determined that worms fed with high-glucose diets show alterations in glucose content and uptake, triglyceride content, body size, number of eggs laid, egg-laying defects, and signs of oxidative stress and accelerated aging. Additionally, we analyzed the participation of different key regulators of carbohydrate and lipid metabolism, oxidative stress and longevity such as SKN-1/NRF2, HIF-1/HIF1α, SBP-1/SREBP, CRH-1/CREB, CEP-1/p53, and DAF-16/FOXO, in the reduction of lifespan in glucose-fed worms.
高糖指数饮食以及久坐不动的生活方式被认为是导致人类肥胖、2 型糖尿病和心血管疾病的决定因素。这些饮食已被证明以依赖胰岛素信号的方式缩短秀丽隐杆线虫的寿命，但其他信号通路的参与尚未得到解决。在这项研究中，我们已经确定，喂食高糖饮食的线虫表现出葡萄糖含量和摄取、甘油三酯含量、体型、产卵数量、产卵缺陷以及氧化应激和加速衰老的迹象的改变。此外，我们还分析了碳水化合物和脂质代谢、氧化应激和长寿的不同关键调节剂，如 SKN-1/NRF2、HIF-1/HIF1α、SBP-1/SREBP、CRH-1/CREB、CEP-1/p53 和 DAF-16/FOXO，在葡萄糖喂养的线虫寿命缩短中的参与。
