Shi Meng-Meng, Chen Yun-Tian, Wang Xiao-Dan, Zhang Yun-Feng, Cheng Ting, Chen Hui, Sun Feng, Bao Hong, Chen Rong, Xiong Wei-Ning, Song Yuan-Lin, Li Qing-Yun, Qu Jie-Ming
Department of Respiratory and Critical Care Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Rui Jin Er Road, Shanghai, 200025, China.
Institute of Respiratory Diseases, Shanghai Jiao Tong University School of Medicine, 197 Rui Jin Er Road, Shanghai, 200025, China.
J Clin Biochem Nutr. 2023 Nov;73(3):228-233. doi: 10.3164/jcbn.23-32. Epub 2023 Aug 18.
Clinical studies had found that hydrogen/oxygen mixed inhalation was beneficial to ameliorate the respiratory symptoms in the adjuvant treatment of patients with COVID-19. We aimed to explore the efficacy of hydrogen/oxygen therapy in favoring the recovery of Omicron SARS-CoV-2 variant infection. There were 64 patients who randomly assigned to receive hydrogen/oxygen inhalation (32 patients) and oxygen inhalation (32 patients). The average shedding duration of Omicron in hydrogen/oxygen group was shorter than oxygen group. The trend of cumulative negative conversion rate of Omicron increased gradually after the third day. The IL-6 levels in hydrogen/oxygen group decreased by 22.8% compared with the baseline. After hydrogen/oxygen mixed gas inhalation, the lymphocyte count increased to 61.1% of the baseline on the 3rd day in the hydrogen/oxygen group. More patients in the hydrogen/oxygen group had resolution of pulmonary lesions. Our study showed the beneficial trends of molecular hydrogen in treating patients with COVID-19, which may offer a prospective solution to adjuvant therapy for COVID-19 Patients.
临床研究发现，氢氧混合吸入有助于改善新型冠状病毒肺炎患者辅助治疗中的呼吸道症状。我们旨在探讨氢氧疗法对奥密克戎 SARS-CoV-2 变异株感染恢复的疗效。64 例患者被随机分为氢氧吸入组（32 例）和氧气吸入组（32 例）。氢氧组奥密克戎的平均脱落持续时间短于氧气组。第三天后，奥密克戎的累积转阴率呈逐渐上升趋势。氢氧组白细胞介素 -6 水平较基线下降了 22.8%。氢氧混合气体吸入后，氢氧组第 3 天淋巴细胞计数增加至基线的 61.1%。氢氧组有更多患者肺部病变得到缓解。我们的研究显示了分子氢治疗新型冠状病毒肺炎患者的有益趋势，这可能为新型冠状病毒肺炎患者的辅助治疗提供一种前瞻性解决方案。
