Department of General Surgery, The Fourth Affiliated Hospital, Zhejiang University School of Medicine, Yiwu, 322000, China.
The Fourth Affiliated Hospital, Zhejiang University School of Medicine, Yiwu, Zhejiang, 322000, China.
Adv Mater. 2024 Feb;36(5):e2308286. doi: 10.1002/adma.202308286. Epub 2023 Nov 28.
Cancer represents a serious disease with significant implications for public health, imposing substantial economic burden and negative societal consequences. Compared to conventional cancer treatments, such as surgery and chemotherapy, energy-based therapies (ET) based on athermal and thermal ablation provide distinct advantages, including minimally invasive procedures and rapid postoperative recovery. Nevertheless, due to the complex pathophysiology of many solid tumors, the therapeutic effectiveness of ET is often limited. Nanotechnology offers unique opportunities by enabling facile material designs, tunable physicochemical properties, and excellent biocompatibility, thereby further augmenting the outcomes of ET. Numerous nanomaterials have demonstrated the ability to overcome intrinsic therapeutic resistance associated with ET, leading to improved antitumor responses. This comprehensive review systematically summarizes the underlying mechanisms of ET-associated resistance (ETR) and highlights representative applications of nanoplatforms used to mitigate ETR. Overall, this review emphasizes the recent advances in the field and presents a detailed account of novel nanomaterial designs in combating ETR, along with efforts aimed at facilitating their clinical translation.
癌症是一种严重的疾病，对公共健康有重大影响，造成了巨大的经济负担和负面的社会后果。与传统的癌症治疗方法，如手术和化疗相比，基于热消融和冷消融的能量治疗（ET）具有明显的优势，包括微创程序和快速术后恢复。然而，由于许多实体瘤的复杂病理生理学，ET 的治疗效果往往受到限制。纳米技术通过实现简便的材料设计、可调的物理化学性质和优异的生物相容性，提供了独特的机会，从而进一步提高了 ET 的效果。许多纳米材料已经证明能够克服与 ET 相关的内在治疗抵抗，从而提高抗肿瘤反应。这篇综述系统地总结了 ET 相关抵抗（ETR）的潜在机制，并强调了用于减轻 ETR 的纳米平台的代表性应用。总的来说，这篇综述强调了该领域的最新进展，并详细介绍了新型纳米材料设计在对抗 ETR 方面的应用，以及为促进其临床转化所做的努力。
