肠聚集性大肠杆菌中 VI 型分泌系统的合成、组装、收缩或拆卸不涉及任何健身成本。
No fitness cost entailed by type VI secretion system synthesis, assembly, contraction, or disassembly in enteroaggregative .
机构信息
Laboratoire d'Ingénierie des Systèmes Macromoléculaires (LISM, UMR 7255), Institut de Microbiologie de la Méditerranée (IMM), Aix Marseille Univ, CNRS, Marseille, France.
出版信息
J Bacteriol. 2023 Dec 19;205(12):e0035723. doi: 10.1128/jb.00357-23. Epub 2023 Nov 16.
Abstract
Bacteria use weapons to deliver effectors into target cells. One of these weapons, the type VI secretion system (T6SS), assembles a contractile tail acting as a spring to propel a toxin-loaded needle. Due to its size and mechanism of action, the T6SS was intuitively thought to be energetically costly. Here, using a combination of mutants and growth measurements in liquid medium, on plates, and in competition experiments, we show that the T6SS does not entail a growth cost to enteroaggregative .
摘要
细菌使用武器将效应物递送至靶细胞。其中一种武器，即 VI 型分泌系统（T6SS），组装成一个收缩的尾部充当弹簧，将装满毒素的针推进。由于其大小和作用机制，T6SS 直观地被认为是能量消耗大的。在这里，我们使用突变体和液体培养基、平板和竞争实验中的生长测量相结合的方法，表明 T6SS 不会对肠聚集. 产生生长代价。
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