Zhou Nengneng, Wang Lei, Zhao Fangli, Gao Xiang, Zhao Xiaowei, Zhang Man
Key Laboratory of Functionalized Molecular Solids, Ministry of Education, Anhui Key Laboratory of Molecule-Based Materials, College of Chemistry and Materials Science, Anhui Normal University, Wuhu, Anhui 241000, China.
J Org Chem. 2023 Dec 1;88(23):16556-16565. doi: 10.1021/acs.joc.3c02086. Epub 2023 Nov 16.
Herein, an N-heterocyclic carbene (NHC)-catalyzed tandem cyclization/addition/cyclization reaction of 2-isocyanobiaryls and α-bromo-N-cinnamylamides for the synthesis of 2-pyrrolidinone-functionalized phenanthridines is developed. This protocol features a radical cascade process, broad substrate scope, and good functional group compatibility under metal- and oxidant-free reaction conditions.
在此，开发了一种用于合成2-吡咯烷酮官能化菲啶的N-杂环卡宾（NHC）催化的2-异氰基联芳基与α-溴-N-肉桂酰胺的串联环化/加成/环化反应。该方法具有自由基级联过程、广泛的底物范围以及在无金属和无氧化剂的反应条件下良好的官能团兼容性。
