Zhang Qijing, Lei Hao, Zhou Cong-Ying, Wang Chengming
College of Chemistry and Materials Science, Jinan University, Guangzhou, Guangdong 510632, China.
College of Chemistry and Materials Science, Guangdong Provincial Key Laboratory of Functional Supramolecular Coordination Materials and Applications, Jinan University, Guangzhou, Guangdong 510632, China.
Org Lett. 2022 Jul 1;24(25):4615-4619. doi: 10.1021/acs.orglett.2c01729. Epub 2022 Jun 22.
-Polyheterocycles are rapidly accessed by -heterocyclic carbene (NHC) catalysis through regioselective sequential radical addition/cyclization in the absence of any metals or oxidants. The transformation occurs under mild conditions and enjoys a wide substrate scope with excellent functional group compatibility. Furthermore, a gram-scale synthesis is also conducted. Preliminary mechanistic studies reveal the potential involvement of an NHC radical cation intermediate.
