Department of Marine Environmental Science, Chungnam National University, Daejeon 34134, Republic of Korea.
School of Earth and Environmental Sciences & Research Institute of Oceanography, Seoul National University, Seoul 08826, Republic of Korea.
Environ Sci Technol. 2023 Dec 5;57(48):19148-19155. doi: 10.1021/acs.est.3c05035. Epub 2023 Nov 16.
Effect-directed analysis (EDA) combined with nontarget screening (NTS) has established a valuable tool for the identification of unmonitored toxic substances in environmental samples. It consists of three main steps: (1) highly potent fraction identification, (2) toxicant candidate selection, and (3) major toxicant identification. Here, we discuss the methodology, current status, limitations, and future challenges of EDA combined with NTS. This method has been applied successfully to various environmental samples, such as sediments, wastewater treatment plant effluents, and biota. We present several case studies and highlight key results. EDA has undergone significant technological advancements in the past 20 years, with the establishment of its key components: target chemical analysis, bioassays, fractionation, NTS, and data processing. However, it has not been incorporated widely into environmental monitoring programs. We provide suggestions for the application of EDA combined with NTS in environmental monitoring programs and management, with the identification of further research needs.
效应导向分析（EDA）结合非靶向筛查（NTS）已经成为识别环境样品中未监测到的有毒物质的一种有价值的工具。它包括三个主要步骤：（1）高活性部分鉴定，（2）候选毒物选择，和（3）主要毒物鉴定。在这里，我们讨论 EDA 结合 NTS 的方法学、现状、局限性和未来挑战。该方法已成功应用于各种环境样品，如沉积物、污水处理厂出水和生物群。我们提出了几个案例研究并强调了关键结果。在过去的 20 年中，EDA 经历了重大的技术进步，其关键组成部分已经建立：目标化学分析、生物测定、分级、NTS 和数据处理。然而，它尚未广泛纳入环境监测计划。我们为 EDA 结合 NTS 在环境监测计划和管理中的应用提供了建议，并确定了进一步的研究需求。
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