胆囊收缩素、蛙皮素和降钙素对未生育、哺乳期及断奶后雌性大鼠食物摄入量的影响

The effect of cholecystokinin, bombesin and calcitonin on food intake in virgin, lactating and postweaning female rats.

作者信息

Wager-Srdar S A, Morley J E, Levine A S

出版信息

Peptides. 1986 Sep-Oct;7(5):729-34. doi: 10.1016/0196-9781(86)90086-0.

Abstract

During lactation food intake increases greatly without an accompanying large increase in body weight; therefore, this physiological state is an excellent example of non-obese hyperphagia. In the present study, we found that cholecystokinin (CCK-8) decreased food intake in lactating and virgin female rats. However, female rats were more resistant to the effect of CCK on eating following weaning of the pups. Bombesin (BB) suppressed food intake in virgin female rats and in lactating rats during early and mid lactation. Rats were resistant to its satiating effect during late lactation and during the postweaning period. Calcitonin potently suppressed food intake in virgin, lactating and postweaning rats. The present findings suggest that CCK and bombesin decrease food intake more effectively in virgin female rats and during earlier phases of lactation than during late lactation or postweaning.

摘要

在哺乳期，食物摄入量大幅增加，但体重却没有相应大幅增加；因此，这种生理状态是非肥胖性食欲亢进的一个典型例子。在本研究中，我们发现胆囊收缩素（CCK - 8）可减少泌乳期和未生育雌性大鼠的食物摄入量。然而，幼崽断奶后，雌性大鼠对CCK抑制进食的作用更具抗性。蛙皮素（BB）可抑制未生育雌性大鼠以及泌乳早期和中期泌乳大鼠的食物摄入量。在泌乳后期和断奶后时期，大鼠对其饱腹感作用具有抗性。降钙素可有效抑制未生育、泌乳和断奶后大鼠的食物摄入量。目前的研究结果表明，与泌乳后期或断奶后相比，CCK和蛙皮素在未生育雌性大鼠以及泌乳早期减少食物摄入量的效果更显著。