Morley J E, Levine A S, Hertel H, Tandeski T, Seal U S
Peptides. 1986 Nov-Dec;7(6):969-72. doi: 10.1016/0196-9781(86)90122-1.
In the studies reported here we demonstrate that bombesin decreases food intake in wolf (Canis lupus) pups without altering glucose or insulin levels. A high dose of cholecystokinin-octapeptide (CCK, 5 micrograms/kg) decreased food intake. CCK produced a transient increase in insulin, without altering glucose. Glucagon (0.5 mg/kg) failed to decrease food intake despite producing a marked hyperglycemia and hyperinsulinemia. Calcitonin was ineffective at decreasing food intake, although it did decrease the time spent feeding. These studies suggest a potential role for peripheral peptides in food regulation in the wolf.
在本报告的研究中，我们证明蛙皮素可减少狼崽的食物摄入量，而不会改变血糖或胰岛素水平。高剂量的八肽胆囊收缩素（CCK，5微克/千克）可减少食物摄入量。CCK使胰岛素短暂升高，而不改变血糖。胰高血糖素（0.5毫克/千克）尽管导致明显的高血糖和高胰岛素血症，但未能减少食物摄入量。降钙素在减少食物摄入量方面无效，尽管它确实减少了进食时间。这些研究表明外周肽在狼的食物调节中可能发挥作用。
