Avery D D, Livosky M
Pharmacol Biochem Behav. 1986 Jul;25(1):7-11. doi: 10.1016/0091-3057(86)90221-2.
Patterns of dietary self-selection were examined in adult female rats following peripheral injections of either bombesin (BBS) (6, 10, 14 and 16 micrograms) or cholecystokinin octapeptide (CCK-8) (0.75, 1.5, 2.25, and 3.0 micrograms). Animals were food deprived for 18 hours and then offered three isocaloric diets (protein, carbohydrate, and fat) following injections of peptides. Each subject received each of 4 doses of both peptides in a within-subjects design. All doses of BBS decreased total food intake and fat intake 30 minutes following injections. Also at this time period the two highest doses suppressed carbohydrate intake, while protein was unaffected. Cumulative intake at one hour revealed that total intake remained suppressed. The two highest doses continued to suppress carbohydrate intake, while only the 14 micrograms dose continued to suppress fat intake. Additionally protein was now significantly suppressed by all doses. The three highest doses of CCK-8 produced a decrease in total food intake and fat intake 30 minutes after injections. By one hour, only total intake remained suppressed but only with administration of the highest dose. Results are interpreted as providing support for the notion that BBS and CCK are physiological satiety signals and that they maintain unique functions in regulating food intake.
在成年雌性大鼠外周注射蛙皮素（BBS）（6、10、14和16微克）或八肽胆囊收缩素（CCK - 8）（0.75、1.5、2.25和3.0微克）后，对其饮食自我选择模式进行了研究。动物禁食18小时，然后在注射肽后提供三种等热量饮食（蛋白质、碳水化合物和脂肪）。在受试者内设计中，每个受试者接受两种肽的4种剂量。注射后30分钟，所有剂量的BBS均降低了总食物摄入量和脂肪摄入量。同样在此时间段，两个最高剂量抑制了碳水化合物摄入量，而蛋白质摄入量未受影响。一小时时的累积摄入量显示总摄入量仍受到抑制。两个最高剂量继续抑制碳水化合物摄入量，而只有14微克剂量继续抑制脂肪摄入量。此外，所有剂量现在均显著抑制了蛋白质摄入量。注射后30分钟，CCK - 8的三个最高剂量使总食物摄入量和脂肪摄入量减少。到一小时时，只有总摄入量仍受到抑制，但仅在给予最高剂量时如此。研究结果被解释为支持以下观点：BBS和CCK是生理性饱腹感信号，并且它们在调节食物摄入方面具有独特功能。
