Hospital for Infectious Diseases in Warsaw, Warsaw, Poland.
Department of Infectious Diseases, Tropical Diseases and Hepatology, Medical University of Warsaw, Warsaw, Poland.
J Immigr Minor Health. 2024 Feb;26(1):15-22. doi: 10.1007/s10903-023-01559-1. Epub 2023 Nov 16.
In recent years, especially as a result of war in Ukraine, enormous movements of migration to Poland from eastern European countries have been reported, including people living with Human Immunodeficiency Virus (HIV). We have conducted multi-center, prospective study, which aimed to establish HIV-1 subtype and assess the presence of primary drug resistance mutations to nucleoside reverse transcriptase inhibitors, non-nucleoside reverse transcriptase inhibitors and protease inhibitors in antiretroviral treatment naïve patients. The clinical trial recruited 117 individuals during 2 years period (2020-2022). The prevalence of HIV-1 subtype A was statistically significantly more frequent in Ukrainian, and HIV-1 subtype B in Polish patients (p < 0.05). Drug resistance mutations were detected in 44% of all cases and the comparison of presence of mutations in the analyzed groups, as well as in the subgroups of subtype A and B HIV-1 has not revealed any significant differences (p > 0.05), nevertheless Polish patients had multidrug resistance mutations more frequent (p < 0.05). The results from our trial show no increased risk of transmission of multidrug resistant HIV strains in our cohort of Ukrainian migrants.Clinical trials. Gov number NCT04636736; date of registration: November 19, 2020.
近年来，尤其是由于乌克兰战争，有报道称大量来自东欧国家的移民涌入波兰，其中包括艾滋病毒（HIV）感染者。我们进行了一项多中心、前瞻性研究，旨在确定 HIV-1 亚型，并评估初治患者中核苷逆转录酶抑制剂、非核苷逆转录酶抑制剂和蛋白酶抑制剂的原发性耐药突变的存在情况。临床试验在 2020 年至 2022 年期间招募了 117 名患者。乌克兰患者中 HIV-1 亚型 A 的流行率明显更高，而波兰患者中 HIV-1 亚型 B 的流行率更高（p<0.05）。在所有病例中，有 44%检测到耐药突变，对分析组、HIV-1 亚型 A 和 B 亚组中突变的存在进行比较，未发现任何显著差异（p>0.05），但波兰患者更常出现多药耐药突变（p<0.05）。我们的试验结果表明，在我们的乌克兰移民队列中，没有发现传播多药耐药 HIV 株的风险增加。临床试验。 gov 编号 NCT04636736；注册日期：2020 年 11 月 19 日。
