General Surgery, Cancer Center, Department of Hepatobiliary & Pancreatic Surgery and Minimally Invasive Surgery, Affiliated People's Hospital, Zhejiang Provincial People's Hospital, Hangzhou Medical College, Hangzhou, 310014, Zhejiang, China.
Department of Gastroenterology, The Fifth Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, China.
BMC Cancer. 2023 Nov 16;23(1):1116. doi: 10.1186/s12885-023-11621-8.
Platelet distribution width (PDW), but not platelet count, was found to more comprehensively reflect platelet activity. The present study, thus, aimed to evaluate the prognostic value of PDW to lymphocyte ratio (PDWLR) in patients with hepatocellular carcinoma (HCC) following hepatectomy.
Patients following hepatectomy were analyzed retrospectively. The Kaplan-Meier survival curves and Cox regression model were used to determine the prognostic value of PDWLR.
241 patients were analyzed eventually, and stratified into low and high PDWLR groups (≤ 9.66 vs. > 9.66). Results of comparing the baseline characteristics showed that high PDWLR was significantly associated with cirrhosis, and intraoperative blood loss (all P < 0.05). In multivariate COX regression analysis, PDWLR was demonstrated as an independent risk factor for OS (HR: 1.549, P = 0.041) and RFS (HR: 1.655, P = 0.005). Moreover, PDWLR demonstrated a superior capacity for predicting prognosis compared to other indicators.
Preoperative PDWLR has a potential value in predicting the prognosis of HCC patients following hepatectomy, which may help in clinical decision-making for individual treatment.
血小板分布宽度（PDW）而非血小板计数，被发现能更全面地反映血小板活性。因此，本研究旨在评估 PDW 与淋巴细胞比值（PDWLR）在肝癌（HCC）患者肝切除术后的预后价值。
回顾性分析接受肝切除术的患者。采用 Kaplan-Meier 生存曲线和 Cox 回归模型确定 PDWLR 的预后价值。
最终分析了 241 例患者，并将其分为低 PDWLR 组（≤9.66）和高 PDWLR 组（>9.66）。比较基线特征的结果显示，高 PDWLR 与肝硬化和术中出血量显著相关（均 P<0.05）。多因素 COX 回归分析显示，PDWLR 是 OS（HR：1.549，P=0.041）和 RFS（HR：1.655，P=0.005）的独立危险因素。此外，PDWLR 预测预后的能力优于其他指标。
术前 PDWLR 对预测 HCC 患者肝切除术后的预后具有潜在价值，可能有助于个体化治疗的临床决策。
