Pan Yan, Wang Yingjian, Wang Yanzhong, Xu Shoufang, Jiang Feiyu, Han Yetao, Hu Mengsi, Liu Zhiwei
Department of Blood Transfusion, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People's Hospital, 100 Minjiang Road, Quzhou, 324000, Zhejiang, China.
Department of Blood Transfusion, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, 3 East Qingchun Road, Hangzhou, 310016, Zhejiang, China.
Clin Transl Oncol. 2023 Apr;25(4):873-881. doi: 10.1007/s12094-022-03014-3. Epub 2022 Nov 23.
Platelet-derived microvesicles (PMVs), the microvesicles with the highest concentration in the bloodstream, play a key role in the regulation of hemostasis, inflammation, and angiogenesis. PMVs have recently been identified as key factors in the link between platelets and cancer. PMVs bind to both cancer cells and nontransformed cells in the microenvironment of the tumor, and then transfer platelet-derived contents to the target cell. These contents have the potential to either stimulate or modulate the target cell's response. PMVs are encased in a lipid bilayer that contains surface proteins and lipids as well as components found inside the PMV. Each of these components participates in known and potential PMV roles in cancer. The complicated roles played by PMVs in the onset, development, and progression of cancer and cancer-related comorbidities are summarized in this study.
血小板衍生微泡（PMVs）是血液中浓度最高的微泡，在止血、炎症和血管生成的调节中起关键作用。PMVs最近被确定为血小板与癌症之间联系的关键因素。PMVs与肿瘤微环境中的癌细胞和未转化细胞结合，然后将血小板衍生的内容物转移到靶细胞。这些内容物有可能刺激或调节靶细胞的反应。PMVs包裹在脂质双层中，脂质双层包含表面蛋白和脂质以及PMV内部发现的成分。这些成分中的每一种都参与了PMVs在癌症中已知和潜在的作用。本研究总结了PMVs在癌症及其相关合并症的发生、发展和进展中所起的复杂作用。
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