Schulich School of Medicine and Dentistry, Western University, London, Canada.
Children's Health Research Institute, Lawson Health Research Institute, London, Canada.
Int J Aging Hum Dev. 2024 Oct;99(3):267-286. doi: 10.1177/00914150231208689. Epub 2023 Nov 16.
Social exposures are linked to an array of health outcomes, especially around aging. In this study, we examined the association of social capital, defined as social relationships and networks, with clinical and biological outcomes including cognitive health, oral inflammation, and epigenetic aging. We used data from the Canadian Longitudinal Study on Aging (CLSA) ( = 1,479; aged 45-85 years), categorizing social capital as structural and cognitive capital. Oral inflammation was determined as the presence of gum bleeding. Epigenetic aging was computed as the difference between chronological age and DNA methylation age. We constructed multivariable regression models adjusted for covariates to assess the relationships of interest. Higher structural social capital was associated with decelerated epigenetic aging and better cognitive health outcomes, while higher cognitive social capital was associated with better cognitive outcomes and less oral inflammation. Enhanced social capital may contribute to better clinical and biological outcomes around aging.
社会因素与多种健康结果有关，尤其是衰老相关的健康结果。在这项研究中，我们研究了社会资本（定义为社会关系和网络）与临床和生物学结果的关系，包括认知健康、口腔炎症和表观遗传衰老。我们使用了来自加拿大老龄化纵向研究（CLSA）的数据（n=1479，年龄在 45-85 岁之间），将社会资本分为结构性和认知性资本。口腔炎症通过牙龈出血来确定。表观遗传衰老通过比较 DNA 甲基化年龄和实际年龄来计算。我们构建了多变量回归模型来调整协变量，以评估相关关系。较高的结构性社会资本与表观遗传衰老减速和认知健康结果改善有关，而较高的认知性社会资本与认知结果改善和口腔炎症减少有关。增强社会资本可能有助于改善衰老相关的临床和生物学结果。
