Valencia-Nieto Laura, López-de la Rosa Alberto, González-García María J, López-Miguel Alberto
Instituto de Oftalmobiología Aplicada (IOBA), Universidad de Valladolid, Valladolid, Spain.
Departamento de Física Teórica, Atómica y Óptica, Facultad de Ciencias, Universidad de Valladolid, Valladolid, Spain.
Ophthalmic Physiol Opt. 2024 Jan;44(1):124-130. doi: 10.1111/opo.13243. Epub 2023 Nov 17.
To assess the reliability and agreement of non-invasive break-up time (NIBUT) in symptomatic and asymptomatic contact lens (CL) wearers using automatic objective and conventional subjective techniques.
In this prospective cross-sectional study, soft CL wearers, classified into symptomatic and asymptomatic based on the Contact Lens Dry Eye Questionnaire-8, underwent NIBUT assessment with the CL in situ. The CA-800 Corneal Analyzer and the EasyTear® VIEW+ Tearscope were used for objective and subjective evaluation, respectively. The within-subject repeatability and intraclass correlation coefficient (ICC) were calculated. The agreement between the devices was compared using the Bland-Altman method.
A total of 141 CL wearers (51 male and 90 female) with a mean age of 33.6 (SD = 12.2) years were included. The repeatability and ICC values obtained with the CA-800 device when measuring NIBUT were 5.4 s and 58.6% across the whole sample, 4.2 s and 48.8% for the asymptomatic group and 7.1 s and 68.4% for the symptomatic group. When using the subjective method (EasyTear®), the respective repeatability and ICC values were 7.3 s and 32.7% for the whole sample, 6.5 s and 30.4% for the asymptomatic group and 8.6 s and 35.9% for the symptomatic group. The CA-800 device provided significantly (p < 0.001) shorter NIBUT values compared with EasyTear® for the whole sample (3.3 [2.9] vs. 8.1 [3.4] s), the asymptomatic (3.3 [3.0] vs. 7.7 [3.6] s) and the symptomatic (3.8 [2.9] vs. 8.6 [3.0] s) groups.
Objective (CA-800) NIBUT assessment provides more reliable measurements than the conventional subjective technique using the EasyTear® device. However, CL practitioners should also be aware that the objective method indicates shorter NIBUT values. Symptomatic CL wearers may also need a higher number of NIBUT measurements to obtain reliable estimations.
使用自动客观技术和传统主观技术评估有症状和无症状隐形眼镜佩戴者的无创泪膜破裂时间（NIBUT）的可靠性和一致性。
在这项前瞻性横断面研究中，根据隐形眼镜干眼问卷-8将软性隐形眼镜佩戴者分为有症状和无症状两组，佩戴隐形眼镜时进行NIBUT评估。分别使用CA-800角膜分析仪和EasyTear® VIEW+泪膜镜进行客观和主观评估。计算受试者内重复性和组内相关系数（ICC）。使用Bland-Altman方法比较两种设备之间的一致性。
共纳入141名隐形眼镜佩戴者（51名男性和90名女性），平均年龄33.6（标准差=12.2）岁。使用CA-800设备测量NIBUT时，整个样本的重复性和ICC值分别为5.4秒和58.6%，无症状组为4.2秒和48.8%，有症状组为7.1秒和68.4%。使用主观方法（EasyTear®）时，整个样本的重复性和ICC值分别为7.3秒和32.7%，无症状组为6.5秒和30.4%，有症状组为8.6秒和35.9%。与EasyTear®相比，CA-800设备在整个样本（3.3 [2.9] 秒对8.1 [3.4] 秒）、无症状组（3.3 [3.0] 秒对7.7 [3.6] 秒）和有症状组（3.8 [2.9] 秒对8.6 [3.0] 秒）中提供的NIBUT值显著更短（p < 0.001）。
客观（CA-800）NIBUT评估比使用EasyTear®设备的传统主观技术提供更可靠的测量结果。然而，隐形眼镜从业者也应意识到客观方法显示的NIBUT值更短。有症状的隐形眼镜佩戴者可能也需要更多次数的NIBUT测量才能获得可靠的估计值。
