Huovinen Venla, Aatsinki Anna-Katariina, Kataja Eeva-Leena, Munukka Eveliina, Keskitalo Anniina, Lamichhane Santosh, Raunioniemi Peppi, Bridgett David J, Lahti Leo, O'Mahony Siobhain M, Dickens Alex, Korja Riikka, Karlsson Hasse, Nolvi Saara, Karlsson Linnea
Department of Clinical Medicine, Psychiatry, FinnBrain Birth Cohort Study, Turku Brain and Mind Center, University of Turku, Turku, Finland.
Centre for Population Health Research, Turku University Hospital and University of Turku, Turku, Finland.
Dev Psychopathol. 2024 Oct;36(4):2016-2031. doi: 10.1017/S0954579423001396. Epub 2023 Nov 17.
Studies indicate that gut microbiota is related to neurodevelopmental and behavioral outcomes. Accordingly, early gut microbiota composition (GMC) has been linked to child temperament, but research is still scarce. The aim of this study was to examine how early GMC at 2.5 months is associated with child negative and fear reactivity at 8 and 12 months since they are potentially important intermediate phenotypes of later child psychiatric disorders.
Our study population was 330 infants enrolled in the longitudinal FinnBrain Birth Cohort Study. Gut microbiota composition was analyzed using stool sample 16s rRNA sequencing. Negative and fear reactivity were assessed using the Laboratory Temperament Assessment Battery (Lab-TAB) at child's age of 8 months ( =150) and the Infant Behavior Questionnaire-Revised Short Form (IBQ-R SF) at child's age of 12 months ( = 276).
We found a positive association between alpha diversity and reported fear reactivity and differing microbial community composition based on negative reactivity for boys. Isobutyric acid correlated with observed negative reactivity, however, this association attenuated in the linear model. Several genera were associated with the selected infant temperament traits. This study adds to the growing literature on links between infant gut microbiota and temperament informing future mechanistic studies.
研究表明，肠道微生物群与神经发育和行为结果相关。因此，早期肠道微生物群组成（GMC）与儿童气质有关，但相关研究仍然较少。本研究的目的是探讨2.5个月时的早期GMC如何与8个月和12个月时儿童的负面和恐惧反应性相关，因为它们可能是后期儿童精神疾病的重要中间表型。
我们的研究人群为330名纳入芬兰大脑出生队列纵向研究的婴儿。使用粪便样本16s rRNA测序分析肠道微生物群组成。在儿童8个月大时（n = 150）使用实验室气质评估量表（Lab-TAB），在儿童12个月大时（n = 276）使用修订版婴儿行为问卷简表（IBQ-R SF）评估负面和恐惧反应性。
我们发现α多样性与报告的恐惧反应性之间存在正相关，并且基于男孩的负面反应性存在不同的微生物群落组成。异丁酸与观察到的负面反应性相关，然而，这种关联在线性模型中减弱。几个菌属与选定的婴儿气质特征相关。这项研究增加了关于婴儿肠道微生物群与气质之间联系的文献，为未来的机制研究提供了信息。
