University of Rochester School of Medicine and Dentistry.
Department of Psychiatry and Human Behavior, Alpert Medical School, Brown University.
Dev Psychol. 2024 Nov;60(11):2052-2061. doi: 10.1037/dev0001718. Epub 2024 Mar 28.
Fear reactivity is an early emerging temperament trait that predicts longer term behavioral and health outcomes. The current analysis tests the hypothesis, an extension of prior research on maternal immune activation (MIA), that the prenatal maternal immune system is a reliable predictor of observed fear reactivity in infancy. The analysis is based on a prospective longitudinal cohort study that collected data from the first trimester and conducted observational assessments of temperament at approximately 12 months of age ( = 281 infants). MIA was assessed from immune biomarkers measured in maternal blood at each trimester; infant temperament was assessed using the Laboratory Temperament Assessment Battery assessment at 12 months; covariates included family and sociodemographic factors. Patterns of inflammatory markers across gestation reliably predicted observed temperament: elevated prenatal MIA was associated with high fear reactivity to novel stimuli. The findings provide novel evidence of prenatal origins of fear reactivity and suggest developmental mechanisms that may underlie early emerging individual differences in child temperament. (PsycInfo Database Record (c) 2024 APA, all rights reserved).
恐惧反应性是一种早期出现的气质特征，可预测长期的行为和健康结果。本分析检验了一个假设，即对母体免疫激活 (MIA) 的先前研究的扩展，即产前母体免疫系统是婴儿期观察到的恐惧反应性的可靠预测指标。该分析基于一项前瞻性纵向队列研究，该研究从第一个三个月期收集数据，并在大约 12 个月大时进行气质的观察评估（= 281 名婴儿）。MIA 是根据每个三个月期从母体血液中测量的免疫生物标志物来评估的；婴儿气质是在 12 个月时使用实验室气质评估电池评估来评估的；协变量包括家庭和社会人口因素。整个孕期炎症标志物的模式可靠地预测了观察到的气质：升高的产前 MIA 与对新刺激的高恐惧反应性有关。这些发现为恐惧反应性的产前起源提供了新的证据，并提出了可能是儿童气质早期出现个体差异的发展机制。（PsycInfo 数据库记录（c）2024 APA，保留所有权利）。
