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新冠疫情与平缓曲线:一种反馈控制视角

Covid-19 and Flattening the Curve: A Feedback Control Perspective.

作者信息

Di Lauro Francesco, Kiss Istvan Zoltan, Rus Daniela, Della Santina Cosimo

机构信息

Department of MathematicsUniversity of Sussex Brighton BN1 9QH U.K.

MIT Computer Science and Artificial Intelligence LaboratoryMassachusetts Institute of Technology Cambridge MA 02139 USA.

出版信息

IEEE Control Syst Lett. 2020 Nov 19;5(4):1435-1440. doi: 10.1109/LCSYS.2020.3039322. eCollection 2021 Oct.

DOI:10.1109/LCSYS.2020.3039322
PMID:37974563
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8545053/
Abstract

Many of the policies that were put into place during the Covid-19 pandemic had a common goal: to flatten the curve of the number of infected people so that its peak remains under a critical threshold. This letter considers the challenge of engineering a strategy that enforces such a goal using control theory. We introduce a simple formulation of the optimal flattening problem, and provide a closed form solution. This is augmented through nonlinear closed loop tracking of the nominal solution, with the aim of ensuring close-to-optimal performance under uncertain conditions. A key contribution of this letter is to provide validation of the method with extensive and realistic simulations in a Covid-19 scenario, with particular focus on the case of Codogno - a small city in Northern Italy that has been among the most harshly hit by the pandemic.

摘要

在新冠疫情期间实施的许多政策都有一个共同目标

使感染人数曲线趋于平缓,以便其峰值保持在临界阈值以下。本文探讨了运用控制理论制定实现这一目标的策略所面临的挑战。我们提出了最优平缓问题的一种简单表述形式,并给出了封闭形式的解。通过对标称解进行非线性闭环跟踪对其进行了扩展,目的是在不确定条件下确保接近最优的性能。本文的一个关键贡献是在新冠疫情场景中通过广泛且现实的模拟对该方法进行验证,尤其关注科多尼奥的情况——意大利北部的一个小城,是受疫情冲击最严重的地区之一。

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本文引用的文献

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The Impact of Contact Structure and Mixing on Control Measures and Disease-Induced Herd Immunity in Epidemic Models: A Mean-Field Model Perspective.接触结构和混合对传染病模型中控制措施和疾病诱导群体免疫的影响:均值场模型视角。
Bull Math Biol. 2021 Oct 15;83(11):117. doi: 10.1007/s11538-021-00947-8.
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Optimal timing of one-shot interventions for epidemic control.最佳时机的一次性干预措施对控制疫情。
PLoS Comput Biol. 2021 Mar 18;17(3):e1008763. doi: 10.1371/journal.pcbi.1008763. eCollection 2021 Mar.
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Robust and optimal predictive control of the COVID-19 outbreak.对新冠疫情的稳健且最优预测控制
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Fear, lockdown, and diversion: Comparing drivers of pandemic economic decline 2020.恐惧、封锁与转移:2020年大流行经济衰退驱动因素比较
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A systematic review and meta-analysis of published research data on COVID-19 infection fatality rates.对已发表的关于 COVID-19 感染病死率的研究数据的系统回顾和荟萃分析。
Int J Infect Dis. 2020 Dec;101:138-148. doi: 10.1016/j.ijid.2020.09.1464. Epub 2020 Sep 29.
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COVID-19 outbreak response, a dataset to assess mobility changes in Italy following national lockdown.COVID-19 疫情应对,评估意大利全国封锁后流动性变化的数据集。
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