一个巴掌拍不响：神经纤维瘤中肥大细胞与施万细胞的相互作用
It takes two to tango: mast cell and Schwann cell interactions in neurofibromas.
作者信息
Viskochil David H
机构信息
Department of Pediatrics, School of Medicine, University of Utah, Salt Lake City, Utah 84112, USA.
出版信息
J Clin Invest. 2003 Dec;112(12):1791-3. doi: 10.1172/JCI20503.
Abstract
Neurofibromas are benign tumors comprised primarily of Schwann cells and fibroblasts. Mast cell infiltration is a well-known phenomenon; however, their role in tumor pathogenesis has been enigmatic. In an elegant set of experiments using cells derived from a murine model of neurofibromatosis 1 (NF1), Yang et al. dissect the molecular pathways involved in mast cell migration to neurofibromin-deficient Schwann cells. These results set the stage for rational development of therapeutics that could influence the multicellular microenvironment of neurofibromas to inhibit the development and/or progression of these tumors in human NF1.
摘要
神经纤维瘤是主要由施万细胞和成纤维细胞组成的良性肿瘤。肥大细胞浸润是一种众所周知的现象；然而，它们在肿瘤发病机制中的作用一直是个谜。在一系列使用源自1型神经纤维瘤病（NF1）小鼠模型的细胞进行的精妙实验中，杨等人剖析了肥大细胞迁移至缺乏神经纤维瘤蛋白的施万细胞所涉及的分子途径。这些结果为合理开发治疗方法奠定了基础，这些治疗方法可能会影响神经纤维瘤的多细胞微环境，从而抑制人类NF1中这些肿瘤的发生和/或进展。
相似文献
1
It takes two to tango: mast cell and Schwann cell interactions in neurofibromas.一个巴掌拍不响：神经纤维瘤中肥大细胞与施万细胞的相互作用
J Clin Invest. 2003 Dec;112(12):1791-3. doi: 10.1172/JCI20503.
2
Neurofibromin-deficient Schwann cells secrete a potent migratory stimulus for Nf1+/- mast cells.神经纤维瘤蛋白缺陷的施万细胞分泌一种对Nf1+/-肥大细胞有强大作用的迁移刺激因子。
J Clin Invest. 2003 Dec;112(12):1851-61. doi: 10.1172/JCI19195.
3
S100B and neurofibromin immunostaining and X-inactivation patterns of laser-microdissected cells indicate a multicellular origin of some NF1-associated neurofibromas.S100B 和神经纤维瘤蛋白免疫染色以及激光微切割细胞的 X 染色体失活模式表明，一些 NF1 相关神经纤维瘤具有多细胞起源。
J Neurosci Res. 2011 Sep;89(9):1451-60. doi: 10.1002/jnr.22654. Epub 2011 Jun 14.
4
Neurofibroma-associated growth factors activate a distinct signaling network to alter the function of neurofibromin-deficient endothelial cells.神经纤维瘤相关生长因子激活一个独特的信号网络，以改变神经纤维瘤蛋白缺陷型内皮细胞的功能。
Hum Mol Genet. 2006 Jun 1;15(11):1858-69. doi: 10.1093/hmg/ddl108. Epub 2006 Apr 28.
5
The angiogenic factor midkine is aberrantly expressed in NF1-deficient Schwann cells and is a mitogen for neurofibroma-derived cells.血管生成因子中期因子在神经纤维瘤病1型（NF1）缺陷的施万细胞中异常表达，并且是神经纤维瘤来源细胞的促分裂原。
Oncogene. 2001 Jan 4;20(1):97-105. doi: 10.1038/sj.onc.1204026.
6
The activation of the WNT signaling pathway is a Hallmark in neurofibromatosis type 1 tumorigenesis.WNT 信号通路的激活是神经纤维瘤病 1 型肿瘤发生的标志。
Clin Cancer Res. 2014 Jan 15;20(2):358-71. doi: 10.1158/1078-0432.CCR-13-0780. Epub 2013 Nov 11.
7
8
Decreased expression of neurofibromin contributes to epithelial-mesenchymal transition in neurofibromatosis type 1.神经纤维瘤病 1 型中神经纤维瘤蛋白表达减少促进上皮间质转化。
Exp Dermatol. 2010 Aug;19(8):e136-41. doi: 10.1111/j.1600-0625.2009.01017.x.
9
Nf1-dependent tumors require a microenvironment containing Nf1+/-- and c-kit-dependent bone marrow.Nf1基因依赖型肿瘤需要一个包含Nf1+/-和c-kit基因依赖型骨髓的微环境。
Cell. 2008 Oct 31;135(3):437-48. doi: 10.1016/j.cell.2008.08.041.
10
Influence of hormones and hormone metabolites on the growth of Schwann cells derived from embryonic stem cells and on tumor cell lines expressing variable levels of neurofibromin.激素和激素代谢产物对源自胚胎干细胞的雪旺细胞生长以及对表达不同水平神经纤维瘤蛋白的肿瘤细胞系生长的影响。
Dev Dyn. 2008 Feb;237(2):513-24. doi: 10.1002/dvdy.21430.
引用本文的文献
1
An Unusual Intraosseous Swelling of the Jaw: Two Rare Case Reports.颌骨罕见的骨内肿胀：两例病例报告
Indian J Otolaryngol Head Neck Surg. 2023 Dec;75(4):4032-4040. doi: 10.1007/s12070-023-04023-6. Epub 2023 Jul 4.
2
Single-cell RNA sequencing of neurofibromas reveals a tumor microenvironment favorable for neural regeneration and immune suppression in a neurofibromatosis type 1 porcine model.神经纤维瘤的单细胞RNA测序揭示了1型神经纤维瘤病猪模型中有利于神经再生和免疫抑制的肿瘤微环境。
Front Oncol. 2023 Sep 25;13:1253659. doi: 10.3389/fonc.2023.1253659. eCollection 2023.
3
After loss in Schwann cells, inflammation drives neurofibroma formation.雪旺细胞缺失后，炎症促使神经纤维瘤形成。
Neurooncol Adv. 2019 Nov 22;2(Suppl 1):i23-i32. doi: 10.1093/noajnl/vdz045. eCollection 2020 Jul.
4
Cutaneous neurofibromas in the genomics era: current understanding and open questions.在基因组学时代的皮肤神经纤维瘤：当前的认识和未解决的问题。
Br J Cancer. 2018 Jun;118(12):1539-1548. doi: 10.1038/s41416-018-0073-2. Epub 2018 Apr 26.
5
Conditional Inactivation of Pten with EGFR Overexpression in Schwann Cells Models Sporadic MPNST.雪旺细胞中PTEN条件性失活与EGFR过表达模拟散发型恶性外周神经鞘膜瘤
Sarcoma. 2012;2012:620834. doi: 10.1155/2012/620834. Epub 2012 Dec 18.
6
The plexiform neurofibroma microenvironment.丛状神经纤维瘤微环境
Cancer Microenviron. 2012 Dec;5(3):307-10. doi: 10.1007/s12307-012-0115-x. Epub 2012 Jul 24.
7
PTEN and NF1 inactivation in Schwann cells produces a severe phenotype in the peripheral nervous system that promotes the development and malignant progression of peripheral nerve sheath tumors.PTEN 和 NF1 在 Schwann 细胞中的失活会导致外周神经系统出现严重表型，从而促进周围神经鞘瘤的发展和恶性进展。
Cancer Res. 2012 Jul 1;72(13):3405-13. doi: 10.1158/0008-5472.CAN-11-4092. Epub 2012 Jun 14.
8
Ulcerative colitis and neurofibromatosis type 1 with bilateral psoas muscle neurofibromas: a case report.溃疡性结肠炎与1型神经纤维瘤病伴双侧腰大肌神经纤维瘤：一例报告
J Res Med Sci. 2009 Jul;14(4):261-5.
9
Occipital peripheral nerve stimulation in the management of chronic intractable occipital neuralgia in a patient with neurofibromatosis type 1: a case report.1型神经纤维瘤病患者慢性顽固性枕神经痛的枕部周围神经刺激治疗：一例报告
J Med Case Rep. 2011 May 10;5:174. doi: 10.1186/1752-1947-5-174.
10
Solitary fibrous tumor of the oral cavity: clinicopathologic and immunohistochemical study of 21 cases.口腔孤立性纤维瘤：21例临床病理及免疫组化研究
Head Neck Pathol. 2009 Jun;3(2):106-15. doi: 10.1007/s12105-009-0111-8. Epub 2009 Apr 28.
本文引用的文献
1
Neurofibromin-deficient Schwann cells secrete a potent migratory stimulus for Nf1+/- mast cells.神经纤维瘤蛋白缺陷的施万细胞分泌一种对Nf1+/-肥大细胞有强大作用的迁移刺激因子。
J Clin Invest. 2003 Dec;112(12):1851-61. doi: 10.1172/JCI19195.
2
ON THE RELATIONSHIP OF MAST CELLS TO VARIOUS SOFT TISSUE TUMOURS.论肥大细胞与各种软组织肿瘤的关系。
Br J Cancer. 1964 Dec;18(4):686-91. doi: 10.1038/bjc.1964.79.
3
Mast cells in peripheral nerve trunks.外周神经干中的肥大细胞。
Nature. 1961 Mar 4;189:766-7. doi: 10.1038/189766a0.
4
Inflammation and cancer.炎症与癌症。
Nature. 2002;420(6917):860-7. doi: 10.1038/nature01322.
5
Neurofibromas in NF1: Schwann cell origin and role of tumor environment.1型神经纤维瘤病中的神经纤维瘤：施万细胞起源及肿瘤环境的作用
Science. 2002 May 3;296(5569):920-2. doi: 10.1126/science.1068452.
6
Inflammatory cells and cancer: think different!炎症细胞与癌症：另辟蹊径！
J Exp Med. 2001 Mar 19;193(6):F23-6. doi: 10.1084/jem.193.6.f23.
7
Tumorigenic properties of neurofibromin-deficient neurofibroma Schwann cells.神经纤维瘤蛋白缺陷型神经纤维瘤雪旺细胞的致瘤特性。
Am J Pathol. 2001 Feb;158(2):501-13. doi: 10.1016/S0002-9440(10)63992-2.
8
Schwann cells harbor the somatic NF1 mutation in neurofibromas: evidence of two different Schwann cell subpopulations.雪旺细胞在神经纤维瘤中存在体细胞NF1突变：两种不同雪旺细胞亚群的证据。
Hum Mol Genet. 2000 Dec 12;9(20):3055-64. doi: 10.1093/hmg/9.20.3055.
9
Genetic and cellular defects contributing to benign tumor formation in neurofibromatosis type 1.导致1型神经纤维瘤病良性肿瘤形成的遗传和细胞缺陷。
Hum Mol Genet. 2000 Apr 12;9(7):1059-66. doi: 10.1093/hmg/9.7.1059.
10
The hallmarks of cancer.癌症的特征
Cell. 2000 Jan 7;100(1):57-70. doi: 10.1016/s0092-8674(00)81683-9.
Zotero 插件