Trivedi Sonal Dilip, Shukla Shivang, Pandya Shivam V, Mehta Jeet Sandeep, Pandya Shashank J, Sharma Mohit, Patel Shailesh, Warikoo Vikas, Rathod Priyank, Puj Ketul S, Salunkhe Abhijeet, Patel Keval, Thottiyen Salahudheen, Aaron Jebin, Pawar Ajinkya
Department of surgical oncology, GCRI, Haripura, Asarwa, Ahmedabad 380016 India.
Indian J Otolaryngol Head Neck Surg. 2023 Dec;75(4):3415-3420. doi: 10.1007/s12070-023-04001-y. Epub 2023 Jun 24.
Malignant melanoma is an aggressive malignancy of melanocytes which is usually found on sun exposed areas of the body. A rare variant of this disease with no etiological association is the mucosal malignant melanoma found on all mucosal surfaces of the body including the oral cavity, respiratory mucosa and anorectal region. In the head and neck region, this disease is almost always diagnosed at an advanced stage and requires a very high index of suspicion for diagnosis. It is more commonly found in females than males.Indians are more prone to this disease as compared to Caucasians.Due to the obscure location within the oral and nasal cavity, it is clinically found at an advanced stage and requires surgical resection with adequate margins for complete eradication. This may be achieved either endoscopically in the nasal cavity or with wide local resection in the oral cavity. this in certain cases may not be feasible due to vicinity of vital structures. In such cases, adjuvant radiotherapy helps in the local control of disease. Histopathological evaluation of the specimen helps to determine aggressive biology of tumor with factors such as presence of ulceration, nodular morphology and perineural invasion being high risk features for development of local and regional recurrence.
The online version contains supplementary material available at 10.1007/s12070-023-04001-y.
恶性黑色素瘤是黑色素细胞的侵袭性恶性肿瘤，通常发生在身体暴露于阳光下的部位。这种疾病的一种罕见变体，无病因关联，是发生在身体所有黏膜表面（包括口腔、呼吸道黏膜和肛门直肠区域）的黏膜恶性黑色素瘤。在头颈部区域，这种疾病几乎总是在晚期被诊断出来，诊断时需要高度怀疑。女性比男性更易患此病。与白种人相比，印度人更容易患这种疾病。由于其在口腔和鼻腔内位置隐匿，临床上多在晚期发现，需要进行手术切除并保证足够切缘以彻底根除。这可以通过鼻腔内镜手术或口腔广泛局部切除来实现。在某些情况下，由于重要结构临近，这可能不可行。在这种情况下，辅助放疗有助于局部控制疾病。对标本进行组织病理学评估有助于确定肿瘤的侵袭性生物学行为，如溃疡的存在、结节形态和神经周围侵犯等因素是局部和区域复发的高危特征。
在线版本包含可在10.1007/s12070-023-04001-y获取的补充材料。
