用于即时护理（POC）的COVID-19抗体检测的潜在微流控设备：综述
Potential Microfluidic Devices for COVID-19 Antibody Detection at Point-of-Care (POC): A Review.
作者信息
Tayyab Muhammad, Sami Muhammad Ahsan, Raji Hassan, Mushnoori Srinivas, Javanmard Mehdi
机构信息
Department of Electrical and Computer EngineeringRutgers University Piscataway NJ 08854 USA.
Department of Chemical and Biochemical EngineeringRutgers University Piscataway NJ 08854 USA.
出版信息
IEEE Sens J. 2020 Oct 30;21(4):4007-4017. doi: 10.1109/JSEN.2020.3034892. eCollection 2021 Feb 15.
Abstract
COVID-19 has been declared a global pandemic which has brought the world economy and the society to a standstill. The current emphasis of testing is on detection of genetic material of SARS-CoV-2. Such tests are useful for assessing the current state of a subject: Infected or not infected. In addition to such tests, antibody testing is necessary to stratify the population into three groups: never exposed, infected, and immune. Such a stratification is necessary for safely reopening the society and remobilizing the economy. The aim of this review article is to inform the audience of the current diagnostic and surveillance technologies that are being employed for the detection of SARS-CoV-2 antibodies along with their shortcomings, and to highlight microfluidic sensors and devices that show promise of being commercialized for detection and quantification of SARS-CoV-2 antibodies in low-resource and Point-of-Care (POC) settings.
摘要
新型冠状病毒肺炎已被宣布为全球大流行疾病，这使世界经济和社会陷入停滞。目前检测的重点是检测严重急性呼吸综合征冠状病毒2（SARS-CoV-2）的遗传物质。此类检测对于评估受试者的当前状态（感染或未感染）很有用。除了此类检测外，还需要进行抗体检测，以便将人群分为三组：从未接触过、已感染和具有免疫力。这种分层对于安全地重新开放社会和恢复经济活动是必要的。这篇综述文章的目的是向读者介绍目前用于检测SARS-CoV-2抗体的诊断和监测技术及其缺点，并重点介绍在资源匮乏和即时检测（POC）环境中显示出有望商业化用于检测和定量SARS-CoV-2抗体的微流控传感器和设备。
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