Nnamudi Anthony Chibuzor, Orhue Noghayin Jerry, Ijeh Ifeoma Irene, Nwabueze Amarachi Nene
Department of Biochemistry, Faculty of Basic Medical Sciences, PAMO University of Medical Sciences, Port Harcourt, Nigeria.
Department of Biochemistry, Faculty of Life Sciences, University of Benin, Benin City, Nigeria.
J Diabetes Metab Disord. 2023 Jul 7;22(2):1337-1345. doi: 10.1007/s40200-023-01252-y. eCollection 2023 Dec.
Triglyceride-Glucose (TyG) index is a surrogate marker of insulin resistance. This study compared the performance of TyG index and the Finnish diabetes risk score (FINDRISC) in diabetes risk prediction.
This cross-sectional study involved 122 young adults (aged 15-35 years) in Asaba, Delta State, Nigeria. Anthropometric measurements and biochemical analysis were done following standard protocols. Diabetes risk scoring was done using the FINDRISC questionnaire. TyG index was calculated logarithmically. Discrimination between TyG index and FINDRISC was done by plotting receiver operating characteristic (ROC) curves.
High risk participants had significantly (p < 0.001) higher mean values of body mass index (BMI), waist circumference (WC), waist-to-hip ratio (WHR) relative to the lower risk categories. Participants in TyG index Quartile 4 had significantly higher mean values of triglyceride (p < 0.001) and fasting plasma glucose (p < 0.05). BMI and triglyceride had the most significant (p < 0.001) positive correlation with FINDRISC and TyG index, respectively. A moderately elevated to high risk (FINDRISC ≥ 12) of developing diabetes was found in 14.8% of the participants; with a female preponderance (20.6%) relative to males (7.4%). More than half of the participants (52.5%) had slightly elevated risk and differences in diabetes risk susceptibility were significant (p < 0.001) across gender. FINDRISC had an AUC value of 0.826 while TyG index had an AUC value of 0.628 for diabetes risk prediction.
FINDRISC had a better performance than TyG index in the prediction of diabetes risk in this population. The use of other TyG-related parameters rather than TyG index is recommended in future studies.
The online version contains supplementary material available at 10.1007/s40200-023-01252-y.
甘油三酯-葡萄糖（TyG）指数是胰岛素抵抗的替代指标。本研究比较了TyG指数和芬兰糖尿病风险评分（FINDRISC）在糖尿病风险预测中的表现。
这项横断面研究纳入了尼日利亚三角州阿萨巴的122名年轻成年人（年龄15 - 35岁）。按照标准方案进行人体测量和生化分析。使用FINDRISC问卷进行糖尿病风险评分。TyG指数采用对数计算。通过绘制受试者工作特征（ROC）曲线来区分TyG指数和FINDRISC。
高风险参与者的体重指数（BMI）、腰围（WC）、腰臀比（WHR）平均值相对于低风险类别显著更高（p < 0.001）。TyG指数四分位数4的参与者甘油三酯平均值显著更高（p < 0.001），空腹血糖平均值显著更高（p < 0.05）。BMI与FINDRISC的正相关性最显著（p < 0.001），甘油三酯与TyG指数的正相关性最显著（p < 0.001）。14.8%的参与者被发现患糖尿病的风险为中度升高至高风险（FINDRISC≥12）；女性占优势（20.6%），高于男性（7.4%）。超过一半的参与者（52.5%）风险略有升高，不同性别之间糖尿病风险易感性差异显著（p < 0.001）。在糖尿病风险预测中，FINDRISC的AUC值为0.826，而TyG指数的AUC值为0.628。
在该人群中，FINDRISC在糖尿病风险预测方面比TyG指数表现更好。建议在未来研究中使用其他与TyG相关的参数而非TyG指数。
在线版本包含可在10.1007/s40200-023-01252-y获取的补充材料。
