芬兰糖尿病风险评分（FINDRISC）、新诊断糖尿病和低度炎症。
The Finnish Diabetes Risk Score (FINDRISC), incident diabetes and low-grade inflammation.
机构信息
Hospital Israelita Albert Einstein, São Paulo, SP, Brazil.
Hospital Universitario, University of Sao Paulo Medical School, Sao Paulo, Brazil.
出版信息
Diabetes Res Clin Pract. 2021 Jan;171:108558. doi: 10.1016/j.diabres.2020.108558. Epub 2020 Nov 23.
AIMS
The FINDRISC was created to predict the development of type 2 diabetes mellitus (T2DM). Since T2DM associates with inflammation we evaluated if the FINDRISC could predict either current or incident T2DM, and elevated high sensitivity C-reactive protein (hs-CRP).
METHODS
41,880 people (age 41.9 ± 9.7 years; 31% female) evaluated between 2008 and 2016 were included. First, the cross-sectional association between the FINDRISC with presence of either T2DM or hs-CRP ≥ 2.0 mg/L was tested. After a 5 ± 3 years follow-up we tested the score predictive value for incident T2DM and inflammation in respectively 10,559 individuals without diabetes and in a subset of 2,816 individuals having no elevated hs-CRP at baseline.
RESULTS
In the cross sectional analysis the FINDRISC was associated with both T2DM (OR 1.24, 95% CI: 1.23-1.26, P < 0.001) and inflammation (OR 1.10, 95% CI: 1.09-1.11, P < 0.001) per FINDRISC unit, as well as in longitudinal analyses (OR 1.17, 95% CI: 1.14-1.20, P < 0.001; and OR 1.04, 95% CI: 1.02-1.07, P < 0.001; respectively, per FINDRISC unit). The C-statistic for incident T2DM and inflammation was 0.79 (95% CI 0.77-0.82) and 0.55 (95% CI 0.53-0.58), respectively.
CONCLUSION
The FINDRISC shows good discrimination for incident T2DM but less for inflammation.
目的
FINDRISC 旨在预测 2 型糖尿病（T2DM）的发展。由于 T2DM 与炎症有关，我们评估了 FINDRISC 是否可以预测当前或未来的 T2DM，以及高敏 C 反应蛋白（hs-CRP）升高。
方法
共纳入 2008 年至 2016 年评估的 41880 人（年龄 41.9±9.7 岁，31%为女性）。首先，测试 FINDRISC 与 T2DM 或 hs-CRP≥2.0mg/L 存在之间的横断面关联。在 5±3 年的随访后，我们在无糖尿病的 10559 名个体和无基线 hs-CRP 升高的 2816 名个体亚组中分别测试了 FINDRISC 评分对 T2DM 和炎症的预测价值。
结果
在横断面分析中，FINDRISC 与 T2DM（OR 1.24，95%CI：1.23-1.26，P<0.001）和炎症（OR 1.10，95%CI：1.09-1.11，P<0.001）均呈相关，在纵向分析中也是如此（OR 1.17，95%CI：1.14-1.20，P<0.001；OR 1.04，95%CI：1.02-1.07，P<0.001；每 FINDRISC 单位）。发生 T2DM 和炎症的 C 统计量分别为 0.79（95%CI 0.77-0.82）和 0.55（95%CI 0.53-0.58）。
结论
FINDRISC 对 T2DM 的发生具有良好的判别能力，但对炎症的判别能力较差。
Zotero 插件