Festa Alexey A, Storozhenko Olga A, Voskressensky Leonid G, Van der Eycken Erik V
Peoples' Friendship University of Russia (RUDN University), Miklukho-Maklaya st. 6, Moscow, 117198, Russian Federation.
Laboratory for Organic & Microwave-Assisted Chemistry (LOMAC), Department of Chemistry, University of Leuven (KU Leuven), Celestijnenlaan 200F, B-3001, Leuven, Belgium.
Chem Soc Rev. 2023 Dec 11;52(24):8678-8698. doi: 10.1039/d3cs00366c.
The use of visible light and photoredox catalysis emerged as a powerful and sustainable tool for organic synthesis, showing high value for distinctly different ways of bond creation. Halogenated compounds are the cornerstone of contemporary organic synthesis: it is almost impossible to develop a route towards a pharmaceutical reagent, agrochemical, natural product, without the involvement of halogen-containing intermediates. Moreover, the halogenated derivatives as final products became indispensable for drug discovery and materials science. The idea of this review is to understand and summarise the impact of visible light-promoted chemistry on halogenation and halofunctionalisation reactions.
可见光和光氧化还原催化的应用已成为有机合成中一种强大且可持续的工具，在以截然不同的方式形成化学键方面展现出很高的价值。卤代化合物是当代有机合成的基石：几乎不可能在不涉及含卤中间体的情况下开发出一条通往药物试剂、农用化学品、天然产物的路线。此外，卤代衍生物作为最终产品在药物研发和材料科学中变得不可或缺。本综述的目的是理解和总结可见光促进的化学对卤化和卤官能团化反应的影响。
